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Federal
Partial identification by site-directed mutagenesis of a cell growth inhibitory site on the human galectin-1 molecule
U.S. Department of Health & Human Services —
Background Previous work, by us and others, has shown that mammalian galectins-1 have a growth-inhibitory activity for mammalian cells which is apparently independent... -
Federal
Successful immunotherapy with matrix metalloproteinase-derived peptides in adjuvant arthritis depends on the timing of peptide administration
U.S. Department of Health & Human Services —
We have recently found that matrix metalloproteinases (MMPs) are targets for T-cell and B-cell reactivity in experimental arthritis. In the present article, we... -
Federal
Cost-utility of enoxaparin compared with unfractionated heparin in unstable coronary artery disease
U.S. Department of Health & Human Services —
Background Low molecular weight heparins hold several advantages over unfractionated heparin including convenience of administration. Enoxaparin is one such heparin... -
Federal
Functional associations of proteins in entire genomes by means of exhaustive detection of gene fusions
U.S. Department of Health & Human Services —
Background It has recently been shown that the detection of gene fusion events across genomes can be used for predicting functional associations of proteins,... -
Federal
A role of proton transfer in peroxidase-catalyzed process elucidated by substrates docking calculations
U.S. Department of Health & Human Services —
Background Previous kinetic investigations of fungal-peroxidase catalyzed oxidation of N-aryl hydroxamic acids (AHAs) and N-aryl-N-hydroxy urethanes (AHUs) revealed... -
Federal
Induction of apoptosis in rat peripheral blood lymphocytes by the anticancer drug CI-994 (acetyldinaline)
U.S. Department of Health & Human Services —
Abstract CI-994 (acetyldinaline) is an investigational anticancer drug currently in clinical trials. In preclinical safety studies in rats and dogs, CI-994 resulted... -
Federal
Validation and results of a questionnaire for functional bowel disease in out-patients
U.S. Department of Health & Human Services —
Background The aim was to evaluate and validate a bowel disease questionnaire in patients attending an out-patient gastroenterology clinic in Greece. Methods This was... -
Federal
Simultaneous identification of
U.S. Department of Health & Human Services —
Background The glutathione S-transferase (GST) enzyme GSTP1 utilizes byproducts of oxidative stress. We previously showed that alleles of GSTP1 that encode the... -
Federal
The GOLD domain, a novel protein module involved in Golgi function and secretion
U.S. Department of Health & Human Services —
Background Members of the p24 (p24/gp25L/emp24/Erp) family of proteins have been shown to be critical components of the coated vesicles that are involved in the... -
Federal
Reviewing the reviewers: the vague accountability of research ethics committees
U.S. Department of Health & Human Services —
The role of research ethics committees (RECs) is currently strained by increases in the number of protocols that are in need of review, the scientific and funding... -
Federal
Compound 528361: 1,2,3,5-Trithiazine, perhydro, 4,6-dimethyl
U.S. Department of Health & Human Services —
Chemical compound data from PubChem database. IUPAC Name: 4,6-dimethyl-1,2,3,5-trithiazinane. Molecular Formula: C4H9NS3. Molecular Weight: 167.3. This dataset... -
Federal
Compound 527240: Vetiselinenol
U.S. Department of Health & Human Services —
Chemical compound data from PubChem database. IUPAC Name: 2-(4a-methyl-8-methylidene-1,4,5,6,7,8a-hexahydronaphthalen-2-yl)propan-1-ol. Molecular Formula: C15H24O.... -
Federal
The efficacy of chemical agents in cleaning and disinfection programs
U.S. Department of Health & Human Services —
Background Due to the growing number of outbreaks of infection in hospital nurseries, it becomes essential to set up a sanitation program that indicates that the... -
Federal
The challenge of early synovitis: multiple pathways to a common clinical syndrome
U.S. Department of Health & Human Services —
The challenge of early synovitis: multiple pathways to a common clinical syndrome -
Federal
The molecular mechanism of osteoclastogenesis in rheumatoid arthritis
U.S. Department of Health & Human Services —
Bone-resorbing osteoclasts are formed from hemopoietic cells of the monocyte–macrophage lineage under the control of bone-forming osteoblasts. We have cloned an... -
Federal
Differential localization in cells of myosin II heavy chain kinases during cytokinesis and polarized migration
U.S. Department of Health & Human Services —
Background Cortical myosin-II filaments in Dictyostelium discoideum display enrichment in the posterior of the cell during cell migration and in the cleavage furrow... -
Federal
Negative regulation of mitochondrial VDAC channels by C-Raf kinase
U.S. Department of Health & Human Services —
Background Growth of cancer cells results from the disturbance of positive and negative growth control mechanisms and the prolonged survival of these genetically... -
Federal
Regional differences in expression of VEGF mRNA in rat gastrocnemius following 1 hr exercise or electrical stimulation
U.S. Department of Health & Human Services —
Background Vascular endothelial growth factor (VEGF) mRNA levels increase in rat skeletal muscle after a single bout of acute exercise. We assessed regional... -
Federal
Equipment review: Pulmonary uptake and modes of administration of inhaled nitric oxide in mechanically-ventilated patients
U.S. Department of Health & Human Services —
Equipment review: Pulmonary uptake and modes of administration of inhaled nitric oxide in mechanically-ventilated patients -
Federal
The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p
U.S. Department of Health & Human Services —
Background The function of the fission yeast cullins Pcu1p and Pcu4p requires modification by the ubiquitin-related peptide Ned8p. A recent report by Lyapina et al....