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Federal
Loss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressor
U.S. Department of Health & Human Services —
Background The tumor suppressor gene PTEN has been found mutated in many types of advanced tumors. When introduced into tumor cells that lack the wild-type allele of... -
Federal
Is albumin gradient or fluid to serum albumin ratio better than the pleural fluid lactate dehydroginase in the diagnostic of separation of pleural effusion?
U.S. Department of Health & Human Services —
Background To determine the accuracy of serum-effusion albumin gradient (SEAG) and pleural fluid to serum albumin ratio (ALBR) in the diagnostic separation of pleural... -
Federal
Cost-utility of enoxaparin compared with unfractionated heparin in unstable coronary artery disease
U.S. Department of Health & Human Services —
Background Low molecular weight heparins hold several advantages over unfractionated heparin including convenience of administration. Enoxaparin is one such heparin... -
Federal
Detection of fast light-activated H
U.S. Department of Health & Human Services —
Background Proteorhodopsin (pR) is a light-activated proton pump homologous to bacteriorhodopsin and recently discovered in oceanic γ-proteobacteria. One perplexing... -
Federal
Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions
U.S. Department of Health & Human Services —
Background: We have developed and tested a method for printing protein microarrays and using these microarrays in a comparative fluorescence assay to measure the... -
Federal
Low-volume jet injection for intradermal immunization in rabbits
U.S. Department of Health & Human Services —
Background This study tested a low-volume (20–30 μl/20–30 μg DNA) jet injection method for intradermal delivery of a DNA vaccine. Jet injection offers the advantages... -
Federal
Mutational analysis of human profilin I reveals a second PI(4,5)-P
U.S. Department of Health & Human Services —
Background Profilin is a small cytoskeletal protein which interacts with actin, proline-rich proteins and phosphatidylinositol 4,5-bisphosphate (PI(4,5)-P2).... -
Federal
Lack of association between estrogen receptor β dinucleotide repeat polymorphism and autoimmune thyroid diseases in Japanese patients
U.S. Department of Health & Human Services —
Background The autoimmune thyroid diseases (AITDs), such as Graves' disease (GD) and Hashimoto's thyroiditis (HT), appear to develop as a result of complex... -
Federal
Validation and results of a questionnaire for functional bowel disease in out-patients
U.S. Department of Health & Human Services —
Background The aim was to evaluate and validate a bowel disease questionnaire in patients attending an out-patient gastroenterology clinic in Greece. Methods This was... -
Federal
Ultrastructure of acetylcholine receptor aggregates parallels mechanisms of aggregation
U.S. Department of Health & Human Services —
Background Acetylcholine receptors become aggregated at the developing neuromuscular synapse shortly after contact by a motorneuron in one of the earliest... -
Federal
Impact of renal dysfunction on weaning from prolonged mechanical ventilation
U.S. Department of Health & Human Services —
Background: In the intensive care unit (ICU) setting, the combination of mechanical ventilation and renal replacement therapy (RRT) has been associated with prolonged... -
Federal
The GOLD domain, a novel protein module involved in Golgi function and secretion
U.S. Department of Health & Human Services —
Background Members of the p24 (p24/gp25L/emp24/Erp) family of proteins have been shown to be critical components of the coated vesicles that are involved in the... -
Federal
Different effects of antisense RelA p65 and NF-κB1 p50 oligonucleotides on the nuclear factor-κB mediated expression of ICAM-1 in human coronary endothelial and smooth muscle cells
U.S. Department of Health & Human Services —
Background Activation of nuclear factor-κB (NF-κB) is one of the key events in early atherosclerosis and restenosis. We hypothesized that tumor necrosis factor-α... -
Federal
Interactions of pathogens and irritant chemicals in land-applied sewage sludges (biosolids)
U.S. Department of Health & Human Services —
Background Fertilisation of land with processed sewage sludges, which often contain low levels of pathogens, endotoxins, and trace amounts of industrial and household... -
Federal
Inhibition of the MEK1/ERK pathway reduces arachidonic acid release independently of cPLA
U.S. Department of Health & Human Services —
Background The 85-kDa cytosolic phospholipase A2 (cPLA2) mediates arachidonic acid (AA) release in MDCK cells. Although calcium and mitogen-activated protein kinases... -
Federal
Central effects of clozapine in regulating micturition in anesthetized rats
U.S. Department of Health & Human Services —
Background We previously showed that systemic administration of the atypical neuroleptic clozapine in the rat altered a number of urodynamic variables and inhibited... -
Federal
Enhanced immunogenicity of a functional enzyme by T cell epitope modification
U.S. Department of Health & Human Services —
Background T helper epitopes are necessary for the induction of high titers of antigen-specific IgG antibodies. We are interested in the epitope modification of... -
Federal
Pleasure in decision-making situations
U.S. Department of Health & Human Services —
Background This study explores the role of pleasure in decision making. Results In Experiment 1, 12 subjects were presented with a questionnaire containing 46 items... -
Federal
Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases
U.S. Department of Health & Human Services —
Background The human genome contains at least 18 genes for Nudix hydrolase enzymes. Many have similar functions to one another. In order to understand their roles in... -
Federal
Pharmacological and ischemic preconditioning of the human myocardium: mitoK
U.S. Department of Health & Human Services —
Background These studies investigate the role of mitoKATP channels, protein kinase C (PKC) and Mitogen activated protein kinase (p38MAPK) on the cardioprotection of...