This data release includes geochemical, x-ray diffraction mineralogical, and electron probe microanalysis (EPMA) data on rocks, soils, and sediments collected near the Orange Hill and Bond Creek porphyry copper deposits, Nabesna quadrangle, Alaska. Geochemical analyses were completed by a laboratory under contract with the U.S. Geological Survey (USGS). Electron microprobe and x-ray diffraction mineralogical analyses were completed by personnel of the Central Region Minerals Program in Denver, Colorado. The samples were collected and analyzed during 2014 to 2016, selected to help characterize the distribution and composition of mineralized and unmineralized geologic materials in this remote part of the eastern Alaska Range. These results provide important information for interpreting airborne imaging spectroscopy data that were collected as part of the U.S. Geological Survey (USGS) Mineral Resources Program (MRP) project, 'Hyperspectral Remote Sensing Data and a Multi-proxy Investigation for Characterizing Mineral Resources in Alaska'. A discussion and interpretation of these data and their relationship to the airborne spectroscopy results are provided in: Graham, G.E., Kokaly, R.F., Kelley, K.D., Hoefen, T.M., Johnson, M.R., and Hubbard, B.E., Application of imaging spectroscopy for mineral exploration in Alaska: A study over porphyry Cu deposits in the eastern Alaska Range, Economic Geology, in press.