Water velocities and water-quality constituents were measured along planned survey lines, which were generally perpendicular to the shoreline and spaced 100 meters apart, over an approximately 2.3-mile section of nearshore Lake Erie on June 10-12, 2019 (survey 1), and August 19-21, 2019 (survey 2), using a 1200 kHz acoustic Doppler current profiler (ADCP), a YSI 6920 V2 multiparameter sonde, and a YSI EcoMapper autonomous underwater vehicle (AUV). Water-quality data collected in this area included near-surface and three-dimensional measurements of water temperature, specific conductance, pH, dissolved oxygen, turbidity, chlorophyll, and phycocyanin (blue-green algae). The data were geo-referenced with an integrated global navigation satellite system (GNSS) smart antenna with submeter accuracy. The ADCP, multiparameter sonde, and GNSS antenna were mounted on a marine survey vessel, and data were collected as the survey vessel traversed the lake along planned survey lines. The EcoMapper AUV was programmed to follow the same planned survey lines using an undulating dive pattern (a 15-degree dive angle between the surface and 6 feet above the bottom). There was a total of 43 survey lines which typically started about 50 meters offshore and ended 500 meters offshore, and the survey lines covered the area around the mouth of Euclid Creek, Villa Angela Beach, Wildwood Marina, and the Easterly Wastewater Treatment Plant. Data were post-processed using various software and custom MATLAB scripts. Each water-quality measurement has an associated latitude and longitude (WGS84) and sample depth (in feet) below the surface. All water-quality sensors were calibrated per USGS standard methods prior to the start of the survey. These velocity and water-quality measurements were collected over the course of six total days, three in early summer (survey 1) and three in late summer (survey 2), to characterize circulation, mixing, and transport patterns in nearshore Lake Erie in the vicinity of Euclid Creek and Villa Angela Beach. Additionally, continuous measurements of nearshore currents in Lake Erie in the vicinity of Villa Angela Beach and Euclid Creek, Cleveland, Ohio, were recorded during the summer of 2019. Currents were measured every 15 minutes with a 5-minute averaging interval using two different acoustic Doppler velocity meters (ADVM). The individual datasets from each of these instruments are organized as child items in this data release. See each child item page for additional details.