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Universal Protein Resource (UniProt)

Published by National Human Genome Research Institute (NHGRI) | U.S. Department of Health & Human Services | Catalog Last Checked: September 28, 2026 at 08:29 PM
The Universal Protein Resource (UniProt) is a comprehensive and authoritative protein knowledgebase that supports biological and biomedical research. It integrates high‑quality protein sequence data with curated functional annotations, including protein function, domain structure, post‑translational modifications, variant effects, subcellular localization, and involvement in pathways or disease. UniProt’s three major components—UniProtKB, UniRef, and UniParc—allow users to explore deeply curated protein records, analyze non‑redundant protein clusters, and track protein sequence history across databases. Researchers rely on UniProt for tasks such as interpreting genomic variants, identifying protein families, supporting proteomics workflows, and linking protein‑level insights to broader biological systems.

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