Thyroid Hormone Insufficiency Alters the Pattern of Expression of the Ca2+-Binding Proteins in the Rat Neonatal Cortex
Dataset includes various results from two studies: the first study being a pilot study (M1123) and the second including dose response (M1224). In both studies, pregnant rats were dosed with Propylthiouracil (PTU) through drinking water with either 0 and 3ppm PTU (M1123) or 0, 0.5, 1, and 3ppm PTU (M1224) and tissue collected from both pups at various ages and dams on postnatal day 23. Specific results include serum thyroid hormone measures (RIA for thyroid stimulating hormone and LC-MS/MS for the remaining thyroid hormones), cortical thyroid hormone measures (LC-MS/MS), cortical gene expression data (qPCR), body weights, and immunohistochemical cell count data for four stains (DAB staining): parvalbumin, GAD-67, calbindin, and calretinin. Also included are the results for periventricular heterotopia volume measures (NeuN staining with DAB). Cell counts and volume measures for the periventricular heterotopia were conducted using Aperio ImageScope software.
Resources
3 resources available
-
SCIENCE HUB M1123 Dev PTU Parv 0 & 3ppm.xlsx
APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET -
SCIENCE HUB M1123 M1224 PVH.xlsx
APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET -
SCIENCE HUB M1224 PTU Low Dose 2.xlsx
APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "020:00" ] |
| contactPoint |
{ "fn": "Tammy Stoker", "hasEmail": "mailto:stoker.tammy@epa.gov" } |
| description | Dataset includes various results from two studies: the first study being a pilot study (M1123) and the second including dose response (M1224). In both studies, pregnant rats were dosed with Propylthiouracil (PTU) through drinking water with either 0 and 3ppm PTU (M1123) or 0, 0.5, 1, and 3ppm PTU (M1224) and tissue collected from both pups at various ages and dams on postnatal day 23. Specific results include serum thyroid hormone measures (RIA for thyroid stimulating hormone and LC-MS/MS for the remaining thyroid hormones), cortical thyroid hormone measures (LC-MS/MS), cortical gene expression data (qPCR), body weights, and immunohistochemical cell count data for four stains (DAB staining): parvalbumin, GAD-67, calbindin, and calretinin. Also included are the results for periventricular heterotopia volume measures (NeuN staining with DAB). Cell counts and volume measures for the periventricular heterotopia were conducted using Aperio ImageScope software. |
| distribution |
[ { "title": "SCIENCE HUB M1123 Dev PTU Parv 0 & 3ppm.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/d-zpd6/SCIENCE%20HUB%20M1123%20Dev%20PTU%20Parv%200%20%26%203ppm.xlsx" }, { "title": "SCIENCE HUB M1123 M1224 PVH.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/d-zpd6/SCIENCE%20HUB%20M1123%20M1224%20PVH.xlsx" }, { "title": "SCIENCE HUB M1224 PTU Low Dose 2.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/d-zpd6/SCIENCE%20HUB%20M1224%20PTU%20Low%20Dose%202.xlsx" } ] |
| identifier | https://doi.org/10.23719/d-zpd6 |
| keyword |
[ "Adverse Outcome Pathways (AOPs)", "children's health", "developmental neurotoxicity", "in vivo" ] |
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2025-10-14 |
| programCode |
[ "020:000" ] |
| publisher |
{ "name": "U.S. Environmental Protection Agency", "subOrganizationOf": { "name": "U.S. Government" } } |
| references |
null
|
| rights |
null
|
| title | Thyroid Hormone Insufficiency Alters the Pattern of Expression of the Ca2+-Binding Proteins in the Rat Neonatal Cortex |
