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The Role of Hepatic Vagal Tone in Ozone-induced Metabolic Dysfunction in the Liver

Metadata Updated: July 15, 2022

Air pollution has been associated with metabolic diseases and hepatic steatosis-like changes. We have shown that ozone alters liver gene expression for metabolic processes through neuroendocrine activation. This study aimed to further characterize ozone-induced changes and to determine the impact of hepatic vagotomy (HV) which reduces parasympathetic influence. Twelve-week-old male Wistar-Kyoto rats underwent HV or sham surgery five-six days prior to air or ozone exposure (0 or 1 ppm; 4 h/d for one or two days). Ozone-induced lung injury, hyperglycemia, glucose intolerance, circulating lipids and liver global mRNA expression were assessed. mRNA sequencing data are already made publicly available.

This dataset is associated with the following publication: Colonna, C., A. Henriquez, J. House, A. Motsinger-Reif, D. Alewel, A. Fisher, H. Ren, S. Snow, M.C. Schladweiler, D. Miller, C. Miller, P.R. Kodavanti, and U. Kodavanti. The Role of Hepatic Vagal Tone in Ozone-induced Metabolic Dysfunction in the Liver. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 181(2): 229-245, (2021).

Access & Use Information

Public: This dataset is intended for public access and use. License: See this page for license information.

Downloads & Resources

References

https://doi.org/10.1093/toxsci/kfab025

Dates

Metadata Created Date July 15, 2022
Metadata Updated Date July 15, 2022

Metadata Source

Harvested from EPA ScienceHub

Additional Metadata

Resource Type Dataset
Metadata Created Date July 15, 2022
Metadata Updated Date July 15, 2022
Publisher U.S. EPA Office of Research and Development (ORD)
Maintainer
Identifier https://doi.org/10.23719/1521265
Data Last Modified 2021-03-22
Public Access Level public
Bureau Code 020:00
Schema Version https://project-open-data.cio.gov/v1.1/schema
Harvest Object Id b432197d-7552-490d-b0fb-beb30a4c65f0
Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
Harvest Source Title EPA ScienceHub
License https://pasteur.epa.gov/license/sciencehub-license.html
Program Code 020:000
Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
Related Documents https://doi.org/10.1093/toxsci/kfab025
Source Datajson Identifier True
Source Hash 6ae0823e55e68a9c985d439d167a036b9480b9ec
Source Schema Version 1.1

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