This dataset represents the pesticide use within individual local and accumulated upstream catchments for NHDPlusV2 Waterbodies. Catchment boundaries in LakeCat are defined in one of two ways, on-network or off-network. The on-network catchment boundaries follow the catchments provided in the NHDPlusV2 and the metrics for these lakes mirror metrics from StreamCat, but will substitute the COMID of the NHDWaterbody for that of the NHDFlowline. The off-network catchment framework uses the NHDPlusV2 flow direction rasters to define non-overlapping lake-catchment boundaries and then links them through an off-network flow table. This data set is derived from 219, 1-kilometer (km) resolution grids depicting estimated agricultural use of each pesticide in the conterminous United States. Each grid cell value in the national grids of this dataset is the estimated total kilograms (kg) of pesticides applied to row crops, small grain crops and fallow land, pasture and hay crops, and orchard and vineyard crops within the 1- by 1-km area. A single raster was produced using the Raster Calculator Tool adding all 219 grids to form the landscape layer for analysis. The (kilograms of pesticides/square kilometer) was summarized by local catchment and by watershed to produce local catchment-level and watershed-level metrics as a continuous data type.