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The impact of variation in scaling factors on the estimation of internal dose metrics: a case study using bromodichloromethane (BDCM)

Metadata Updated: November 12, 2020

This dataset contains model code and supporting analysis files necessary to evaluate the impact of variability in human hepatic scaling factors. Variation in scaling factor values impacts metabolic rate parameter estimates (Vmax) and hence estimates of internal dose used in dose response analysis and biomarkers of exposure that are important for interpretation of epidemiology studies.

This dataset is associated with the following publication: Kenyon, E., C. Eklund, J. Lipscomb, and R. Pegram. The impact of variation in scaling factors on the estimation of internal dose metrics: a case study using bromodichloromethane (BDCM).1. Toxicology Mechanisms and Methods. Taylor & Francis, Inc., Philadelphia, PA, USA, 26(8): 620-626, (2016).

Access & Use Information

Public: This dataset is intended for public access and use. License: See this page for license information.

Downloads & Resources

References

https://doi.org/10.1080/15376516.2016.1225141

Dates

Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020

Metadata Source

Harvested from EPA ScienceHub

Additional Metadata

Resource Type Dataset
Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020
Publisher U.S. EPA Office of Research and Development (ORD)
Maintainer
Identifier https://doi.org/10.23719/1379171
Data Last Modified 2016-09-01
Public Access Level public
Bureau Code 020:00
Schema Version https://project-open-data.cio.gov/v1.1/schema
Data Dictionary https://pasteur.epa.gov/uploads/10.23719/1379171/documents/DataDictionary_ScalingFactorVariabilityAdult.pdf
Data Dictionary Type application/pdf
Harvest Object Id 9eccef2d-09fd-4981-ae7c-ed0bde849d25
Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
Harvest Source Title EPA ScienceHub
License https://pasteur.epa.gov/license/sciencehub-license.html
Program Code 020:096
Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
Related Documents https://doi.org/10.1080/15376516.2016.1225141
Source Datajson Identifier True
Source Hash e48962404c37b02e2f7469932de4887d40a0f52c
Source Schema Version 1.1

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