The association between PFAS exposure, menstrual cycle parameters, and reproductive hormones in adolescent girls

1) Creatinine (Cr)-corrected luteinizing hormone (LH), estrone-3-glucuronide (E1G), and pregnanediol-3-glucuronide (PdG) levels measured in dried urine strips via immunoassay (ZRT Laboratory, Beaverton, OR), and 2) twenty-four species of perfluoroalkyl and polyfluoroalkyl substances (PFAS) measured via mass spectrometry in serum samples (Environmental Protection Agency, Durham, NC). Participants were healthy adolescents and women residing in the Raleigh-Durham area of NC. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: Datasets generated and/or analyzed during the current study are either included in the published article or are available from the corresponding author on reasonable request. Format: 1) Creatinine (Cr)-corrected luteinizing hormone (LH), estrone-3-glucuronide (E1G), and pregnanediol-3-glucuronide (PdG) levels measured in dried urine strips via immunoassay (ZRT Laboratory, Beaverton, OR), and 2) twenty-four species of perfluoroalkyl and polyfluoroalkyl substances (PFAS; ng/mL) measured via mass spectrometry in serum samples (Environmental Protection Agency, Durham, NC). Participants were healthy adolescents and women residing in the Raleigh-Durham area of NC. This dataset is associated with the following publication: Malave-Ortiz, S., S.A.M. McNeley, S. Denslow, J. Bangma, K.K. Ferguson, S.E. Fenton, and N.D. Shaw. The association between PFAS exposure, menstrual cycle parameters, and reproductive hormones in adolescent girls. Journal of Clinical Endocrinology & Metabolism. Oxford University Press, OXFORD, UK, 111(9): 2502-2512, (2026).

[
  "020:00"
]

{
  "fn": "Jacqueline Bangma",
  "hasEmail": "mailto:bangma.jacqueline@epa.gov"
}

[]

[
  "PFAS",
  "PFBS",
  "human health",
  "serum"
]

[
  "020:000"
]

{
  "name": "U.S. Environmental Protection Agency",
  "subOrganizationOf": {
    "name": "U.S. Government"
  }
}

[
  "https://doi.org/10.1210/clinem/dgag148",
  "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13466940"
]