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    • The Application of a Highly Purified Rat Leydig Cell Assay as a Complement to the H295R Steroidogenesis Assay for the Evaluation of Toxicant Induced Alterations in Testosterone Production

    Metadata Updated: December 13, 2025

    The greater dynamic range of testosterone production in a highly purified rat Leydig cell assay permitted the detection of chemical induced inhibition that was not detected by the high throughput screening format of the H295R steroidogenesis assay. This dataset is associated with the following publication: Klinefelter , G., J. Laskey, and R. Amann. Statin Drugs Markedly Inhibit Testosterone Production by Rat Leydig Cells In Vitro: Implications for Men. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 45: 52-58, (2014). NOTE: This dataset has been removed from public access due to revocation. Please refer inquiries regarding this dataset to the listed contact person.

    Access & Use Information

    Public: This dataset is intended for public access and use. License: See this page for license information.

    Downloads & Resources

    No file downloads have been provided. The publisher may provide downloads in the future or they may be available from their other links.

    Dates

    Metadata Created Date November 12, 2020
    Metadata Updated Date December 13, 2025

    Metadata Source

    Harvested from EPA ScienceHub

    Other Data Resources

    Additional Metadata

    Resource Type Dataset
    Metadata Created Date November 12, 2020
    Metadata Updated Date December 13, 2025
    Publisher U.S. Environmental Protection Agency
    Maintainer
    Identifier https://doi.org/10.23719/1367522
    Data Last Modified 2017-06-16
    Public Access Level public
    Bureau Code 020:00
    Schema Version https://project-open-data.cio.gov/v1.1/schema
    Harvest Object Id 5a29c970-6419-4c27-ad5f-bfbdb45b3c52
    Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
    Harvest Source Title EPA ScienceHub
    License https://pasteur.epa.gov/license/sciencehub-license.html
    Program Code 020:000
    Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency
    Source Datajson Identifier True
    Source Hash 8e2039f9d8d2fd3382b088bc42b48f1f5936492369045ad425d1e632d86f23d6
    Source Schema Version 1.1

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