Symptomatic hemorrhage after alteplase therapy not due to silent ischemia
Background
Stroke thrombolysis-related intracerebral hemorrhage may occur remotely from the anatomical site of ischemia. One postulated mechanism for this is simultaneous multiple embolization with hemorrhage into a "silent" area of ischemia.
Results
A patient suffered a disabling stroke affecting the right cerebral hemisphere. He was treated with intravenous alteplase and underwent extensive early imaging with multimodal MRI. Several hours after treatment he developed a brainstem hemorrhage despite having no evidence of ischemia on DWI MRI in the brainstem.
Conclusion
Not all occurrences of remote ICH after stroke thrombolysis are secondary to multiple emboli with silent ischemia.
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "009:25" ] |
| contactPoint |
{ "fn": "NIH", "@type": "vcard:Contact", "hasEmail": "mailto:info@nih.gov" } |
| description | Background Stroke thrombolysis-related intracerebral hemorrhage may occur remotely from the anatomical site of ischemia. One postulated mechanism for this is simultaneous multiple embolization with hemorrhage into a "silent" area of ischemia. Results A patient suffered a disabling stroke affecting the right cerebral hemisphere. He was treated with intravenous alteplase and underwent extensive early imaging with multimodal MRI. Several hours after treatment he developed a brainstem hemorrhage despite having no evidence of ischemia on DWI MRI in the brainstem. Conclusion Not all occurrences of remote ICH after stroke thrombolysis are secondary to multiple emboli with silent ischemia. |
| distribution |
[ { "@type": "dcat:Distribution", "title": "Official Government Data Source", "mediaType": "text/html", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29099/" } ] |
| identifier | https://healthdata.gov/api/views/86gj-f9f3 |
| issued | 2025-07-13 |
| keyword |
[ "alteplase-therapy", "brainstem-hemorrhage", "intracerebral-hemorrhage", "nih", "stroke-thrombolysis" ] |
| landingPage | https://healthdata.gov/d/86gj-f9f3 |
| modified | 2025-09-06 |
| programCode |
[ "009:036" ] |
| publisher |
{ "name": "National Institutes of Health", "@type": "org:Organization" } |
| theme |
[ "NIH" ] |
| title | Symptomatic hemorrhage after alteplase therapy not due to silent ischemia |
