These data include (1) physical suspended-sediment sample data including suspended silt and clay concentration, suspended-sand concentration, and suspended-sand grain size distribution, (2) bed-sediment sample data with complete grain size analyses, and (3) 15-minute acoustical sediment data measured using a multifrequency array (1MHz and 2MHz) of sidelooking acoustic Doppler profilers which includes suspended silt-and-clay concentration, suspended-sand concentration, and the median grain size of suspended sand, instantaneous silt and clay, and sand loads, and cumulative silt and clay, and sand loads. The acoustic sediment data were calibrated with the physical suspended-sediment samples. These data were collected by the USGS Grand Canyon Monitoring and Research Center, and the USGS Utah Water Science Center and include samples collected between 3/26/2014 and 12/31/2018. Physical suspended-sediment samples and bed-sediment samples were collected using samplers lowered from a boat-mounted crane. Data were collected at Colorado River at Potash (CR_POT) and Green River at Mineral Bottom near Canyonlands National Park, UT (GR_MB).