We applied spatially-explicit models to a spatiotemporally robust dataset of greater sage-grouse (Centrocercus urophasianus) nest locations and fates across wildfire-altered sagebrush ecosystems of the Great Basin ecoregion, western USA. Using sage-grouse as a focal species, we quantified scale-dependent factors driving nest site selection and nest survival across broad spatial scales in order to identify wildfire impacts and other environmental influences on variation in nesting productivity across a broad ecoregion spanning mesic and xeric shrub communities. To investigate the consequences of habitat selection and explore the potential for a source-sink reproductive landscape, we sought to classify nesting habitat on a scale ranging from adaptive (high selection, high survival) to maladaptive (high selection, low survival).