The northeastern North Carolina coastal system, from False Cape, Virginia, to Cape Lookout, North Carolina, has been studied by a cooperative research program that mapped the Quaternary geologic framework of the estuaries, barrier islands, and inner continental shelf. This information provides a basis to understand the linkage between geologic framework, physical processes, and coastal evolution at time scales from storm events to millennia. The study area attracts significant tourism to its parks and beaches, contains a number of coastal communities, and supports a local fishing industry, all of which are impacted by coastal change. Knowledge derived from this research program can be used to mitigate hazards and facilitate effective management of this dynamic coastal system. This regional mapping project produced spatial datasets of high-resolution geophysical (bathymetry, backscatter intensity, and seismic reflection) and sedimentary (core and grab-sample) data. The high-resolution geophysical data were collected during numerous surveys within the back-barrier estuarine system, along the barrier island complex, in the nearshore, and along the inner continental shelf. Sediment cores were taken on the mainland and along the barrier islands, and both cores and grab samples were taken on the inner shelf. Data collection was a collaborative effort between the U.S. Geological Survey (USGS) and several other institutions including East Carolina University (ECU), the North Carolina Geological Survey, and the Virginia Institute of Marine Science (VIMS). The high-resolution geophysical data of the inner continental shelf were collected during six separate surveys conducted between 1999 and 2004 (four USGS surveys north of Cape Hatteras: 1999-045-FA, 2001-005-FA, 2002-012-FA, 2002-013-FA, and two USGS surveys south of Cape Hatteras: 2003-003-FA and 2004-003-FA) and cover more than 2600 square kilometers of the inner shelf. Single-beam bathymetry data was collected north of Cape Hatteras in 1999 using a Knudsen 3.5 kHz echo-sounder. Swath bathymetry data was collected on all other inner shelf surveys using a SEA, Ltd. SwathPLUS 234-kHz bathymetric sonar. Chirp seismic data as well as sidescan-sonar data were collected with a Teledyne Benthos (Datasonics) SIS-1000 north of Cape Hatteras (cruises 1999-045-FA, 2001-005-FA, 2002-012-FA and 2002-013-FA). An Edgetech 512i was used to collect chirp seismic data south of Cape Hatteras (cruises 2003-003-FA and 2004-003-FA) along with a Klein 3000 sidescan-sonar system. Boomer seismic reflection data were collected in both areas. Sediment samples were collected with a Van Veen grab sampler during four of the USGS surveys (1999-045-FA, 2001-005-FA, 2002-013-FA, and 2004-003-FA). Additional sediment core data along the inner shelf are provided from previously published studies. A cooperative study, between the North Carolina Geological Survey and the Minerals Management Service (MMS cores), collected vibracores along the inner continental shelf offshore of Nags Head, Kill Devils Hills and Kitty Hawk, North Carolina in 1996. The U.S. Army Corps of Engineers collected vibracores along the inner shelf offshore of Dare County in August 1995 (NDC cores) and July-August 1995 (SNL cores). These cores are curated by the North Carolina Geological Survey and were used as part of the ground validation process in this study. Nearshore geophysical and core data were collected by the Virginia Institute of Marine Science. The nearshore is defined here as the region between the 10-m isobath and the shoreline. High-resolution bathymetry, backscatter intensity, and chirp seismic data were collected between June 2002 and May 2004. Vibracore samples were collected in May and July 2005. Shallow subsurface geophysical data were acquired along the Outer Banks barrier islands using a ground-penetrating radar (GPR) system. Data were collected by East Carolina University from 2002 to 2005. Rotasonic cores (OBX cores) from five drilling operations were collected from 2002 to 2006 by the North Carolina Geological Survey as part of the cooperative study with the USGS. These cores are distributed throughout the Outer Banks as well as the mainland. The USGS collected seismic data for the Quaternary section within the Albemarle-Pamlico estuarine system between 2001 and 2004 during six surveys (2001-013-FA, 2002-015-FA, 2003-005-FA, 2003-042-FA, 2004-005-FA, and 2004-006-FA). These surveys used Geopulse Boomer and Knudsen Engineering Limited (KEL) 320BR Chirp systems, except cruise 2003-042-FA, which used an Edgetech 424 Chirp and a boomer system. The study area includes Albemarle Sound and selected tributary estuaries such as the South, Pungo, Alligator, and Pasquotank Rivers; Pamlico Sound and trunk estuaries including the Neuse and Pamlico Rivers; and back-barrier sounds including Currituck, Croatan, Roanoke, Core, and Bogue.