This metadata record describes a series of data sets of natural and anthropogenic landscape features linked to NHDPlus Version 2.1’s (NHDPlusV2) approximately 2.7 million stream segments, their associated catchments, and their upstream watersheds within the conterminous United States. The data were linked to four spatial components of NHDPlusV2: individual reach catchments, riparian buffer zones around individual reaches, reach catchments accumulated downstream through the river network, and riparian buffer zones accumulated downstream through the river network. All data can be linked to NHDPlus using the COMID field in these tables and the ComID in the flowline shapefiles or FEATUREID in the catchment ones in the NHDPlus data suite. The datasets were derived using a topologically reconditioned version of the NHDPlusv2 routing network (Schwarz and Wieczorek, 2018). This database is used for the routing of upstream watersheds only. No cartographic changes were made to the original NHDPlusv2 in either the flowline or reach catchment line work. These data are listed under 13 themes which include: 1) Best Management Practices, characteristics such as agricultural management practices and land in conservation practices. 2) Chemical, characteristics such as nitrogen application or toxicity weighted use. 3) Climate and Water Balance Model, characteristics such as model outputs of runoff, actual evapotranspiration or ground water storage. 4) Climate, characteristics such as mean precipitation, temperature, relative humidity, or evapotranspiration. 5) Geology, characteristics such as Hunt or Soller surficial geologies. 6) Hydrologic, characteristics such as base flow or infiltration excess overland flow.Hydrologic Modifications, characteristics such as dam storage or tile drains. 7) Hydrologic Modifications, characteristics such as dam storage or tile drains. 8) Landscape, characteristics such as NLCD, CDL or NWALT. 9) Population Infrastructure, characteristics such as population, housing, and road densities. 10) Regions, characteristics such as EcoRegions, Physiography or Hydrologic Landscapes. 11) Soils, characteristics such as STATSGO, soil salinity, and soil restrictive layer. 12) Topographic Characteristics, characteristics such as basin area, slope and elevation. 13) Water use, characteristics such as estimated freshwater withdrawls and estimated freshwater consumption by thermo-electric power plants These data allow researchers and managers to acquire landscape information for both catchments (for example, the nearby landscape flowing directly into streams) and full upstream watersheds of specific stream reaches anywhere in the within the conterminous United States without having to perform specialized geospatial processing. Aside from comma separated text files, parquet files with the same file structure were also added to each data file under each child item theme. This format will allow researchers to acquire all the information from this data release in an efficient and consistent manner by utilizing and thereby adhering to the FAIR guidelines outlined in Lightsom and others (USGS, 2022).