With recent advancements in prognostics methodologies there has been a significant interest in maturing Prognostics and Health Management (PHM) to increase its technology readiness level for onboard deployments. Active research is underway both in industry and academia to address shortcomings in availability of run-to-failure data, accelerated aging environments, real-time prognostics algorithms, uncertainty representation and management (URM) techniques, prognostics performance evaluation, etc., to name a few. At this juncture it is highly desirable to close the loop by connecting the high level customer requirements for mission planning and execution to performance specifications for prognostics methodologies at the lower technical level. This calls for integrating the pragmatics of safety, reliability, cost, and real-time viability into the prognostics methodologies to establish a connection between top-down and bottom-up approaches currently pursued in the PHM community. In this paper we identify key areas that must be addressed to bridge these gaps and provide an overview of how these areas have been addressed in part at various levels. We also discuss on how these issues can be further developed into a comprehensive and more coherent portfolio of technologies that will ultimately lead to specifying guidelines for prognostics performance.