Report on Evaluation of the Interaction-based Hazard Index Formula with Data on Trihalomethanes
The endpoints selected for evaluation of the HIINT formula were percent relative liver weight of mice (PcLiv) and the logarithm of ALT [Log(ALT)], where the log transformation was used to help stabilize the increases in variance with dose found in the ALT dataset.
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Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[ "020:00" ] |
| contactPoint |
{ "fn": "Tony McDonald", "hasEmail": "mailto:mcdonald.tony@epa.gov" } |
| description | The endpoints selected for evaluation of the HIINT formula were percent relative liver weight of mice (PcLiv) and the logarithm of ALT [Log(ALT)], where the log transformation was used to help stabilize the increases in variance with dose found in the ALT dataset. |
| distribution |
[ { "title": "Appendix A-9_Interact-HI-THMs_2021-01-31.docx", "mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1531675/Appendix%20A-9_Interact-HI-THMs_2021-01-31.docx" } ] |
| identifier | https://doi.org/10.23719/1531675 |
| keyword |
[ "Binary Interaction Weight-of-Evidence", "Dose Additivity", "Hazard Index", "Mixture Effective Dose Estimation", "chemical Mixtures Risk Assessment", "chemical mixtures", "dose addition", "interactions" ] |
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2024-04-23 |
| programCode |
[ "020:000" ] |
| publisher |
{ "name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": { "name": "U.S. Environmental Protection Agency", "subOrganizationOf": { "name": "U.S. Government" } } } |
| references |
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| rights |
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| title | Report on Evaluation of the Interaction-based Hazard Index Formula with Data on Trihalomethanes |
