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Quality control measurements for point-of-care pharmaceutical manufacturing of pain management medicines
This data publication contains the raw and derived data (e.g., extracted peak areas, peak intensities, area ratios, etc.) from microdrop UV-Vis spectroscopy, handheld Raman spectroscopy, liquid chromatography with UV detection, and ambient ionization (direct analysis in real time [DART]) triple quadrupole mass spectrometry analyses of compounded and personalized pain management medicines. These included simple injection saline solutions (fentanyl citrate, benzyl fentanyl hydrochloride, and bupivacaine), adjuvant medicine (diphenhydramine and promethazine tablets), and personalized opioid treatments and tapers (oxycodone tablets and films, buprenorphine films, and 7-day regimens of oxycodone oral films and combined methadone-buprenorphine-naloxone oral films).
*Any mention of commercial products is for information only; it does not imply recommendation or endorsement by NIST.
Resources
5 resources available
-
readme
TXT -
DART-TQ-MS Data
XLSX -
Handheld Raman Data
XLSX -
LC-UV Data
XLSX -
Microdrop UV-Vis Data
XLSX
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "006:55" ] |
| contactPoint |
{ "fn": "Thomas P. Forbes", "hasEmail": "mailto:thomas.forbes@nist.gov" } |
| description | This data publication contains the raw and derived data (e.g., extracted peak areas, peak intensities, area ratios, etc.) from microdrop UV-Vis spectroscopy, handheld Raman spectroscopy, liquid chromatography with UV detection, and ambient ionization (direct analysis in real time [DART]) triple quadrupole mass spectrometry analyses of compounded and personalized pain management medicines. These included simple injection saline solutions (fentanyl citrate, benzyl fentanyl hydrochloride, and bupivacaine), adjuvant medicine (diphenhydramine and promethazine tablets), and personalized opioid treatments and tapers (oxycodone tablets and films, buprenorphine films, and 7-day regimens of oxycodone oral films and combined methadone-buprenorphine-naloxone oral films). *Any mention of commercial products is for information only; it does not imply recommendation or endorsement by NIST. |
| distribution |
[ { "title": "readme", "mediaType": "text/plain", "description": "Description of dataset files and contents", "downloadURL": "https://data.nist.gov/od/ds/mds2-4280/readme.txt" }, { "title": "DART-TQ-MS Data", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "description": "Method details, raw and derived data, and select calculations for direct analysis in real time triple quadrupole mass spectrometry (DART-TQ-MS) quality control measurements of point-of-care produced pharmaceuticals for pain management.", "downloadURL": "https://data.nist.gov/od/ds/mds2-4280/Data%20-%20TQMS.xlsx" }, { "title": "Handheld Raman Data", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "description": "Method details, raw and derived data, and select calculations for handheld Raman quality control measurements of point-of-care produced pharmaceuticals for pain management.", "downloadURL": "https://data.nist.gov/od/ds/mds2-4280/Data%20-%20HandheldRaman.xlsx" }, { "title": "LC-UV Data", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "description": "Method details, raw and derived data, and select calculations for liquid chromatography with UV detection quality control measurements of point-of-care produced pharmaceuticals for pain management.", "downloadURL": "https://data.nist.gov/od/ds/mds2-4280/Data%20-%20LCUV.xlsx" }, { "title": "Microdrop UV-Vis Data", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "description": "Method details, raw and derived data, and select calculations for microdrop UV-Vis spectroscopy quality control measurements of point-of-care produced pharmaceuticals for pain management.", "downloadURL": "https://data.nist.gov/od/ds/mds2-4280/Data%20-%20microdropUVVis.xlsx" } ] |
| identifier | ark:/88434/mds2-4280 |
| issued | 2026-07-31 |
| keyword |
[ "3D printing", "Additive manufacturing", "Distributed manufacturing", "Drop-on-demand", "Drug delivery", "Opioids", "Orodispersible films", "Personalized medicine", "Pharmaceutics", "Printable medicine", "Tablets", "Withdrawal" ] |
| language |
[ "en" ] |
| license | https://www.nist.gov/open/license |
| modified | 2026-07-29 00:00:00 |
| programCode |
[ "006:045" ] |
| publisher |
{ "name": "National Institute of Standards and Technology", "@type": "org:Organization" } |
| theme |
[ "Chemistry:Analytical chemistry", "Health:Pharmaceuticals", "Health:Precision medicine", "Manufacturing:Additive manufacturing", "Manufacturing:Process measurement and control", "Manufacturing:Quality assurance" ] |
| title | Quality control measurements for point-of-care pharmaceutical manufacturing of pain management medicines |
