Patent AT-E399753-T1: [Translated] AMIDES AS PYRUVATE DEHYDROGENASE INHIBITORS
A compound of formula (I):wherein:Ring A is a nitrogen linked mono or bicyclic heterocyclic ring as defined within;R<1 >and R<2 >are independently C1-3alkyl optionally substituted by fluoro or chloro;or R<1 >and R<2 >together with the carbon atom to which they are attached, form a C3-5cycloalkyl ring optionally substituted by fluoro;R<3 >is defined within; andn is 0-5; wherein the values of R<3 >may be the same or different;or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.
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Complete Metadata
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| accessLevel | public |
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"009:25"
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"fn": "NIH/NCBI Data Team",
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| description | A compound of formula (I):wherein:Ring A is a nitrogen linked mono or bicyclic heterocyclic ring as defined within;R<1 >and R<2 >are independently C1-3alkyl optionally substituted by fluoro or chloro;or R<1 >and R<2 >together with the carbon atom to which they are attached, form a C3-5cycloalkyl ring optionally substituted by fluoro;R<3 >is defined within; andn is 0-5; wherein the values of R<3 >may be the same or different;or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed. |
| distribution |
[
{
"@type": "dcat:Distribution",
"title": "Official Data Source",
"mediaType": "text/html",
"description": "Access the complete Patent AT-E399753-T1: [Translated] AMIDES AS PYRUVATE DEHYDROGENASE INHIBITORS on the official website.",
"downloadURL": "https://pubchem.ncbi.nlm.nih.gov/patent/AT-E399753-T1"
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| identifier | https://healthdata.gov/api/views/x757-9i2j |
| issued | 2025-09-05 |
| keyword |
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"chemistry",
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| landingPage | https://healthdata.gov/d/x757-9i2j |
| modified | 2025-09-06 |
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| publisher |
{
"name": "National Center for Biotechnology Information (NCBI)",
"@type": "org:Organization"
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| theme |
[
"NIH"
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|
| title | Patent AT-E399753-T1: [Translated] AMIDES AS PYRUVATE DEHYDROGENASE INHIBITORS |
