This portion of the data release presents a high-resolution orthomosaic image of the coral reef off Waiakane, Molokai, Hawaii. The orthomosaic has a resolution of 2.5 centimeters (cm) per pixel and was derived from structure-from-motion (SfM) processing of aerial imagery collected with an unoccupied aerial system (UAS) on 24 June 2018. The raw imagery used to create the orthomosaic was acquired using a UAS fitted with a Ricoh GR II digital camera featuring a global shutter. The UAS was flown on pre-programmed autonomous flight lines spaced to provide approximately 75 percent overlap between images from adjacent lines. The UAS was flown at an approximate altitude of 100 meters above ground level (AGL), resulting in a nominal ground-sample-distance (GSD) of 2.6 centimeters per pixel. The camera was triggered at 1 Hz using a built-in intervalometer. The raw imagery was geotagged using positions from the UAS onboard single-frequency autonomous GPS. Although imagery was collected using both a circular polarizing filter and with no polarizing filter, only the non-polarized imagery was used for the creation of the orthomosaic. SfM photogrammetry was used to derive a preliminary digital surface model (DSM) from this imagery which was used as a surface for orthorectification and mosaicking. The orthomosaic image is provided in a three-band RGB format, with 8-bit unsigned integer values compressed using high-quality JPEG compression. The image has been formatted as a cloud-optimized GeoTIFF with internal overviews and masks to facilitate cloud-based queries and display.