Use this guide to analyze the National Survey on Drug Use and Health (NSDUH) for yourself. This guide provides data users with information and guidance to properly analyze the NSDUH public use files, including descriptions of the survey scope and design; guidelines for navigating the codebook and other methodological resources; and instructions for basic statistical analyses with common software.OverviewHistory of NSDUH and Trend BreaksNSDUH PopulationsSample Design, Data Collection, and Response RatesSelection of Variables for AnalysisUse of Analysis Weights and Variance Estimation VariablesStatistical Disclosure AvoidanceData SubsettingData PoolingEstimation and Statistical TestingGuidance for Suppressing Unreliable EstimatesCoding ExamplesAppendices provide examples of key indicators measured in NSDUH and a table of important NSDUH resources.