This document is a supplement to the President's FY2022 Budget Request to Congress. Following Congressional mandate, the Supplement incorporates budgetary and programmatic information for member agencies of the NITRD Program and also, for the first time, of the National Artificial Intelligence Initiative. This report covers FY2020 actual investments, FY2021 enacted, and FY2022 requested funding levels by agency and Program Component Area (PCA) for all NITRD R&D programs, as well as describing the key R&D programs and coordination activities planned for FY2022 by the Federal agencies participating in NITRD. This Supplement also reports specific agency investments for FYs 2020–2022 for advanced wireless communications and for AI and the National AI Research Institutes. A separate appendix, the FY2022 Federal Cybersecurity R&D Strategic Plan Implementation Roadmap lists existing and proposed R&D projects that address critical national cybersecurity needs (https://www.nitrd.gov/pubs/FY2022-Cybersecurity-RD-Roadmap.pdf).