This data release contains three tables of U-Pb zircon isotopic data generated from analyses of 40 metaplutonic and metavolcanic rocks from the Yukon-Tanana Upland of western Yukon and east-central Alaska and one sample from southern Yukon. One of the tables also reports U-Pb data for two titanite analyses for one of the samples. U-Pb zircon ages from analyzed samples range from 363.5 ± 3.8 to 253.1 ± 0.7 Ma and were collected from parautochthonous North America and the allochthonous Yukon-Tanana terrane. U-Pb zircon data include 216 individual analyses by ID-TIMS and 35 individual analyses of two samples by LA-ICP-MS. ID-TIMS analyses of titanite give concordant 206Pb-238U ages of 333 and 338 Ma. Two U-Pb tables report the isotopic composition of uranium (U) and thorium (Pb) measured in each grain, ratios of isotopes of lead and uranium isotopes, and the age of each grain. A third table reports interpreted U-Pb ages, sample locations, tectonic assemblage or unit, lithology, analysis method, laboratory used, and basis for age assignment. The data release also contains two tables of whole-rock major- and trace-element geochemical data for metaigneous rocks from the Yukon-Tanana Upland in east-central Alaska for augen gneiss (15 samples) and amphibolite (30 samples).