This dataset contains modeled hourly streamflow in cubic meters per second at each of about eighteen thousand selected operational and water-quality stream gage locations. It was assembled from publicly available retrospective V2.0 National Water Model outputs. The streamflow variable was extracted from model output files and the data were reshaped to optimize read performance. The stream gage locations were derived from several ongoing USGS project gages for evaluation of streamflow, water quality, and real-time monitoring, however only National Water Model identifiers and NHDPlus catchment outlet locations are used to identify model results. Relationships between NWIS gages and National Water Model prediction locations were not reviewed for release at the time of publication of this data. Please contact the author for up to date information. All processing resources used for data reformatting and extraction can be found in this repository: https://code.usgs.gov/water/nwm_subset. This supporting code also contains Docker images that are capable of processing real-time National Water Model outputs into similar formats as this dataset and provide data services via the THREDDS Data Server. The retrospective is available in one NetCDF file. These data conform to the NetCDF-CF Discrete Sampling Geometry conventions. The retrospective data are available from public cloud data outlets (Such as: https://registry.opendata.aws/nwm-archive/). More information on these data are available from the National Water Model v2 release notes here. https://www.weather.gov/media/notification/scn19-42natl_water_model.pdf. The contents of that pdf have been archived with this dataset.