In response to the growing concerns among Chugach communities, contaminant body burden and histopathological condition of chum and sockeye salmon (Oncorhynchus keta and Oncorhynchus nerka) and the shellfish cockles and softshell clams (Clinocardium nuttallii and Mya arenaria) were assessed. The fish and shellfish were collected from traditional subsistence harvest areas in the vicinity of Nanwalek, Port Graham and Seldovia, AK, and were analyzed for trace metals and residues of organic contaminants. Additionally, the fish and shellfish were histologically characterized for the presence, prevalence and severity of tissue pathology, disease, and parasite infections. Data served under this project include measurements of trace elements, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls, DDTs, chlorinated hydrocarbons and histopathology parameters, which include an array of about 30 parasitic taxa (e.g. bucephalus, chlamydia, ciliates, cestodes and nematodes) and 11 diseases (e.g. tumors, neoplasm and necrosis). This project provides invaluable baseline data that is georeferenced and served on the internet through the NOAA's National Status and Trends data portal.