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    • Multipletelophase arrest bypassed (tab)mutants alleviate the essential requirement for Cdc15 in exit from mitosis inS. cerevisiae

    Metadata Updated: September 30, 2025

    The Mitotic Exit Network (MEN) proteins – including the protein kinase Cdc15 and the protein phosphatase Cdc14 – are essential for exit from mitosis inSaccharomyces cerevisiae.To identify downstream targets of the MEN, we soughttelophase arrest bypassed (tab)mutations that bypassed the essential requirement forCDC15.Previous studies identifiednet1tab2-1andCDC14TAB6-1as mutations in the RENT complex subunits Net1 and Cdc14, respectively, and revealed that the MEN acts by promoting release of Cdc14 from its nucleolar Net1 anchor during anaphase. However, the remainingtabmutants were not characterized.

    Access & Use Information

    Public: This dataset is intended for public access and use. License: No license information was provided. If this work was prepared by an officer or employee of the United States government as part of that person's official duties it is considered a U.S. Government Work.

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    Dates

    Metadata Created Date July 24, 2025
    Metadata Updated Date September 30, 2025

    Metadata Source

    Harvested from Healthdata.gov

    Other Data Resources

    Additional Metadata

    Resource Type Dataset
    Metadata Created Date July 24, 2025
    Metadata Updated Date September 30, 2025
    Publisher National Institutes of Health
    Maintainer
    NIH
    Identifier https://healthdata.gov/api/views/8cas-en8t
    Data First Published 2025-07-14
    Data Last Modified 2025-09-29
    Category NIH
    Public Access Level public
    Bureau Code 009:25
    Metadata Context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
    Metadata Catalog ID https://healthdata.gov/data.json
    Schema Version https://project-open-data.cio.gov/v1.1/schema
    Catalog Describedby https://project-open-data.cio.gov/v1.1/schema/catalog.json
    Harvest Object Id d2e36c1f-2cfe-4dcb-ac9c-800e05b6705f
    Harvest Source Id 651e43b2-321c-4e4c-b86a-835cfc342cb0
    Harvest Source Title Healthdata.gov
    Homepage URL https://healthdata.gov/d/8cas-en8t
    Program Code 009:033
    Source Datajson Identifier True
    Source Hash 1d901584077c58e29a6e8be32d10f0c1f5581baa3e43784514326726d1395d41
    Source Schema Version 1.1

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