Mouse fecal microbiome after exposure to high LET radiation

Metadata Updated: March 22, 2019

Space travel is associated with continuous low-dose-rate exposure to high Linear Energy Transfer (LET) radiation. Pathophysiological manifestations after low-dose radiation exposure are strongly influenced by non-cytocidal radiation effects including microbiome and cellular gene expression. Using a mouse model for exposure to high LET radiation we observed substantial changes in the composition and functional potential of the microbiome. These were paralleled by changes in the abundance of multiple metabolites which were related to the enzymatic activity of the altered metagenome by means of metabolic network modeling. There was a complex dynamic in microbial and metabolic composition at different radiation doses suggestive of transient dose-dependent interactions between microbial ecology and signals from the host s cellular damage repair processes. Functional shifts included features associated with dysbiosis at the onset of chronic inflammatory responses which could prMouse fecal microbiome after exposure to high LET radiatione-dispose space travelers to systemic long-term health risks.

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Public: This dataset is intended for public access and use. License: U.S. Government Work

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Metadata Created Date August 1, 2018
Metadata Updated Date March 22, 2019
Data Update Frequency irregular

Metadata Source

Harvested from NASA Data.json

Additional Metadata

Resource Type Dataset
Metadata Created Date August 1, 2018
Metadata Updated Date March 22, 2019
Publisher National Aeronautics and Space Administration
Unique Identifier nasa_genelab_GLDS-146
GeneLab Outreach
Maintainer Email
Public Access Level public
Data Update Frequency irregular
Bureau Code 026:00
Metadata Context
Metadata Catalog ID
Schema Version
Catalog Describedby
Datagov Dedupe Retained 20190322035503
Harvest Object Id 2758a4a9-4737-4116-84ba-e6b1be094bb7
Harvest Source Id 39e4ad2a-47ca-4507-8258-852babd0fd99
Harvest Source Title NASA Data.json
Data First Published 2018-06-26
Homepage URL
Data Last Modified 2018-07-19
Program Code 026:005
Source Datajson Identifier True
Source Hash 2f4b696ff83b4b45e7f4443b31810acfcafd0e8a
Source Schema Version 1.1
Category Earth Science

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