A previously published MODFLOW 2005 groundwater model (https://doi.org/10.3133/sir20185136) of the Rush Springs aquifer was modified to assess the effects of groundwater withdrawals rates on spring discharge, streamflow, and groundwater availability pertaining to the Rush Springs aquifer in and near the Caddo Nation of Oklahoma Tribal jurisdictional area. Increases in industrial and public water supply needs have led to increased development of water resources within the Rush Springs aquifer. As new areas within the aquifer are developed, increased water withdrawals may result in decreases in available water resources and conflicts among water users. The Caddo Nation of Oklahoma is concerned about permitted water transfers from the Rush Springs aquifer in Caddo County to areas outside of this aquifer. The U.S. Geological Survey (USGS), in cooperation with the Caddo Nation of Oklahoma and Bureau of Indian Affairs, assessed four groundwater-withdrawal scenarios and their effects on the Rush Springs aquifer on the Caddo Nation of Oklahoma Tribal jurisdictional area. For the previously published calibrated model, groundwater flow was simulated from 1979 through 2015. In this study, groundwater flow simulations were extended through 2035. The period from 2016 through 2035 is referred to as the 20-year projections. The numerical model contains one steady-state stress period, 444 monthly transient stress periods and 20 annual stress periods. This USGS data release contains all of the input and output files for the simulations described in the associated model documentation report (https://doi.org/10.3133/sir20225044).