MODFLOW-2000 was used within the AnalyzeHOLE program--an integrated wellbore flow analysis tool (https://doi.org/10.3133/tm4F2)--to simulate the 2-D radial flow to each of six wells within three basins at the Fort Irwin National Training Center in San Bernardino County, California. Wellbore flow was simulated for each well by using AnalyzeHOLE to evaluate aquifer properties and heterogeneity. Horizontal layers within the model (hydrogeologic units) were defined based on lithologic and geophysical logs from each well and adjusted during calibration. The majority of the wells were installed in previously underdeveloped or minimally developed groundwater basins. The information gathered from the models provides a basis for developing and constraining basin-scale hydrogeologic-framework and groundwater-flow models that will be used to further evaluate water resources in each groundwater basin. This USGS data release contains all of the input and output files for the AnalyzeHOLE analysis of six wells described in the associated U.S. Geological Survey Scientific Investigations Report 2019-5091 (https://doi.org/10.3133/sir20195091).