An existing three-dimensional model (MODFLOW-2000) by Fine, Petkewich, and Campbell (2017) (https://doi.org/10.3133/sir20175128) was used to evaluate 7 water-management scenarios and predict the effects on the groundwater flow and groundwater-level conditions in the Mount Pleasant, South Carolina area. This model was originally developed in 2007, by Petkewich and Campbell (https://pubs.usgs.gov/publication/sir20075126), then updated and recalibrated to conditions from 1900 to 2015. Results of six previous scenario simulations (scenarios 1-6) for the Mount Pleasant Water Works are published in a U.S. Geological Survey (USGS) Scientific Investigations Report (https://doi.org/10.3133/sir20175128). The archived model input and output files are available in a USGS data release (https://doi.org/10.5066/F7S181FC). Seven additional MODFLOW-2000 scenarios (numbered 7-13), using this updated and recalibrated model, were developed to evaluate different withdrawal strategies which are included in this data release: (7) Mount Pleasant Waterworks bringing online a new well (located at the old well 5 location) at 3.51 million gallons per day (Mgal/d) in 2025; (8) Maximizing withdrawals from Mount Pleasant Waterworks wells 2 and 5 (3.51 Mgal/d each) in 2020 and 2025, respectively; (9) Same as Scenario 7, but removing well 3 from production in 2025; (10) Same as Scenario 9, but removing well 4 from production in 2025 (11) Same as Scenario 7, but converting well 3 to an injection well in 2025 (12) Same as Scenario 11, but converting well 4 to an injection well in 2030; and (13) Same as scenario 8, but with two injection wells added (one in 2025 and one in 2035) to Mount Pleasant Waterworks well field. Nine alternate simulations for scenarios 11-13 (three MODFLOW and six MODPATH) were done to evaluate the effects of different porosity on the groundwater flow system, water levels, and the time-of-travel of particles from injection wells to the main water source. This USGS data release contains all the input and output files for the simulations described above and in the readme.txt file of this data release (https://doi.org/10.5066/P9GZEE4E).