This data release contains input and output data from hydrologic simulations of streamflow conditions in the Red River Basin (RRB) using the Precipitation-Runoff Modeling System (PRMS). The RRB PRMS model predicts components of the water balance at 3065 hydrologic response units (HRU) and streamflow for 1614 stream segments within the model domain for the simulation period 1981 to 2016. The data release contains two shapefiles: (1) a map of HRUs in the model domain and (2) a map of stream segments in the model domain. In addition to the shapefiles, the data release includes files containing the calibrated parameters of the RRB PRMS model as well as model inputs and outputs. The model inputs are (1) climate data, (2) measured streamflow data, (3) water-use data, and (4) land-cover change data. Model outputs include daily time step predictions of groundwater flow, total outflow, surface runoff, and subsurface flow components for each stream segment in the model domain. The model also produces daily estimates of groundwater flow, precipitation, solar radiation, surface runoff, subsurface flow, and outflow; the daily output is aggregated to monthly mean values for each HRU in the model domain. This data release accompanies the documentation of the RRB PRMS model in a U.S. Geological Survey Scientific Investigations Report by Roland (2023).