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Methods and Datasets for 5-Day Oral Anatoxin-a Toxicity in Mice

Published by U.S. Environmental Protection Agency | U.S. Environmental Protection Agency | Catalog Last Checked: August 03, 2026 at 12:52 AM | Dataset Last Updated: May 19, 2026
This contains methods and datasets for serum chemistry, male reproductive assessment, metabolomics, transcriptomics, cortical electrode implantation, BAER testing and behavior assessments for male and female CD-1 mice treated orally for 5 days with either 0, 2, 4, or 6 mg/kg anatoxin-a.

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Complete Metadata
accessLevel public
bureauCode 
[
  "020:00"
]
contactPoint 
{
  "fn": "Donna Jenkins-Hill",
  "hasEmail": "mailto:hill.donna@epa.gov"
}
description This contains methods and datasets for serum chemistry, male reproductive assessment, metabolomics, transcriptomics, cortical electrode implantation, BAER testing and behavior assessments for male and female CD-1 mice treated orally for 5 days with either 0, 2, 4, or 6 mg/kg anatoxin-a.
distribution 
[
  {
    "title": "ANA2_Fig1_Stacks_All_Data.pdf",
    "mediaType": "application/pdf",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/d-kzbz/ANA2_Fig1_Stacks_All_Data.pdf"
  },
  {
    "title": "ATX FOB Dataset.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/d-kzbz/ATX%20FOB%20Dataset.xlsx"
  },
  {
    "title": "ATX Serum Chemistry Results.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/d-kzbz/ATX%20Serum%20Chemistry%20Results.xlsx"
  },
  {
    "title": "ATX Testes Histology Evaluation Report.pdf",
    "mediaType": "application/pdf",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/d-kzbz/ATX%20Testes%20Histology%20Evaluation%20Report.pdf"
  },
  {
    "title": "ATX_5-day Methods_Final_5-19-26.docx",
    "mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/d-kzbz/ATX_5-day%20Methods_Final_5-19-26.docx"
  },
  {
    "title": "Anatoxin Metabolomics Data 20241026.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/d-kzbz/Anatoxin%20Metabolomics%20Data%2020241026.xlsx"
  },
  {
    "title": "Anatoxin NOR Habituation Dataset.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/d-kzbz/Anatoxin%20NOR%20Habituation%20Dataset.xlsx"
  },
  {
    "title": "Anatoxin NOR Testing Dataset.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/d-kzbz/Anatoxin%20NOR%20Testing%20Dataset.xlsx"
  },
  {
    "title": "Anatoxin NOR Training Dataset.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/d-kzbz/Anatoxin%20NOR%20Training%20Dataset.xlsx"
  },
  {
    "title": "Anatoxin Sperm Count Data.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/d-kzbz/Anatoxin%20Sperm%20Count%20Data.xlsx"
  },
  {
    "title": "Anatoxin Sperm Motility Data.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/d-kzbz/Anatoxin%20Sperm%20Motility%20Data.xlsx"
  },
  {
    "title": "biocrates-Quant500-list-of-metabolites-v4-2021.pdf",
    "mediaType": "application/pdf",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/d-kzbz/biocrates-Quant500-list-of-metabolites-v4-2021.pdf"
  }
]
identifier https://doi.org/10.23719/d-kzbz
keyword 
[
  "BAER",
  "Harmful Algal Blooms",
  "Hearing",
  "Neurotoxin",
  "anatoxin",
  "anatoxin-a",
  "auditory testing",
  "brainstem auditory evoked potentials",
  "cyanobacteria",
  "cyanotoxins",
  "functional observational battery",
  "gene expression",
  "harmful algal bloom",
  "health effects",
  "male reproductive effects",
  "metabolomics",
  "neurotoxicity",
  "novel objects recognition",
  "serum chemistry",
  "transcriptomics"
]
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2026-05-19
programCode 
[
  "020:000"
]
publisher 
{
  "name": "U.S. Environmental Protection Agency",
  "subOrganizationOf": {
    "name": "U.S. Government"
  }
}
references 
null
rights 
null
title Methods and Datasets for 5-Day Oral Anatoxin-a Toxicity in Mice

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