This dataset consists of responses to a standardized, web-based survey of partners and potential partners of the South Central Climate Adaptation Science Center (CASC). An initial sample for the survey was compiled from science producers and science users identified by the CASC, Landscape Conservation Cooperative staff and steering committee members with regions that overlapped with the CASC's region, and members of the AFWA Climate Science Committee. A total of 272 individuals were included in the survey sample. One hundred forty-four responded. The survey documented the ways in which partners were engaged with the CASC and the factors affecting their engagement. The survey questions were developed based on insights from the focus groups conducted during the reviews of three previous CASCs and a review of the scholarly literature.