This data release contains five comma separated value (csv) files that describe the location and water-quality data for wells, springs, and streams compiled for the U.S. Geological Survey (USGS) and Oregon Water Resources Department (OWRD) investigation of the groundwater resources of the Harney Basin, Oregon. The data included are site IDs, various site location information, well-construction details and hydrostratigraphy, monitoring status, spring elevation, summarized historic spring discharge, date of each spring discharge measurement, source of the discharge measurement, and results of geochemical analyses for sites sampled as part of the associated USGS Scientific Investigations Report. Some of the data presented here references sections of the the larger work which can be found here: Gingerich, S.B., Johnson, H.M., Boschmann, D.E., Grondin, G.H., and Garcia, C.A., 2022, Groundwater resources of the Harney Basin, southeastern Oregon: U.S. Geological Survey Scientific Investigations Report 2021–5103, 118 p., https://doi.org/10.3133/sir20215103.