In 2007, the U.S. Geological Survey collected 24 vibracores within Apalachicola Bay, Florida. The vibracores were collected using a Rossfelder electric percussive (P-3) vibracore system during a cruise on the R/V Gilbert. Selection of the core sites was based on a geophysical survey that was conducted during 2005 and 2006 in collaboration with the National Oceanic and Atmospheric Administration’s (NOAA) Coastal Services Center (CSC) and the Apalachicola Bay National Estuarine Research Reserve. Available data include the vibracore data logs and photographs, select seismic-reflection profiles (from the geophysical survey), and core-derived data including: grain size analyses, radiocarbon ages, microfossil counts, and sedimentological interpretations. The long-term goal of this study is to provide maps, data, and assistance to the Apalachicola Bay National Estuarine Research Reserve in their effort to monitor and understand the geology and ecology of Apalachicola Bay Estuary. These data will inform coastal managers charged with resource preservation.