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Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening
Dataset for Jesse Rogers et al., 'Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening' published in Environmental Health Perspectives, Vol 133, Issue 6, 067013, June 2025. DOI: https://doi.org/10.1289/EHP16024, PMC12165737
R scripts for reproducing all analyses are available on Github (https://github.com/USEPA/CompTox-HTTr-RCAS). All sequencing data are available via the Gene Expression Omnibus repository (accessionnumbers GSE274318 for U-2 OS and GSE284321 for HepaRG). High-throughput screening assay data are available from InvitroDB via download 29 or the USEPA CompTox Chemicals Dashboard(https://comptox.epa.gov/dashboard/).
This dataset is associated with the following publication:
Rogers, J., J. Bundy, J. Harrill, R. Judson, K. Friedman, and L. Everett. Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 133(6): 067013, (2025).
Resources
3 resources available
-
https://github.com/USEPA/CompTox-HTTr-RCAS
FILE -
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE274318
FILE -
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE284321
FILE
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "020:00" ] |
| contactPoint |
{ "fn": "Logan Everett", "hasEmail": "mailto:everett.logan@epa.gov" } |
| description | Dataset for Jesse Rogers et al., 'Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening' published in Environmental Health Perspectives, Vol 133, Issue 6, 067013, June 2025. DOI: https://doi.org/10.1289/EHP16024, PMC12165737 R scripts for reproducing all analyses are available on Github (https://github.com/USEPA/CompTox-HTTr-RCAS). All sequencing data are available via the Gene Expression Omnibus repository (accessionnumbers GSE274318 for U-2 OS and GSE284321 for HepaRG). High-throughput screening assay data are available from InvitroDB via download 29 or the USEPA CompTox Chemicals Dashboard(https://comptox.epa.gov/dashboard/). This dataset is associated with the following publication: Rogers, J., J. Bundy, J. Harrill, R. Judson, K. Friedman, and L. Everett. Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 133(6): 067013, (2025). |
| distribution |
[ { "title": "https://github.com/USEPA/CompTox-HTTr-RCAS", "accessURL": "https://github.com/USEPA/CompTox-HTTr-RCAS" }, { "title": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE274318", "accessURL": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE274318" }, { "title": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE284321", "accessURL": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE284321" } ] |
| identifier | https://doi.org/10.23719/1532377 |
| keyword |
[ "Hazard Assessment", "chemical prioritization", "high-throughput transcriptomics", "new approach methodologies" ] |
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2025-03-25 |
| programCode |
[ "020:000" ] |
| publisher |
{ "name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": { "name": "U.S. Environmental Protection Agency", "subOrganizationOf": { "name": "U.S. Government" } } } |
| references |
[ "https://doi.org/10.1289/ehp16024", "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165737" ] |
| rights |
null
|
| title | Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening |
