Integrating data gap filling techniques: A case study predicting TEFs for neurotoxicity TEQs to facilitate the hazard assessment of polychlorinated biphenyls
The experimental data were taken from Simon et al., who compiled potency data for effects related to neurotoxicity from four experimental datasets, Stenberg et al. [18] and Wigestrand et al. The measures of potency were EC50 (µM) or IC50 values for all the effects except Stenberg data, which were expressed as a percentage of the control uptake for different concentrations measured.
This dataset is associated with the following publication:
Pradeep, P., L. Carlson, R. Judson, G. Lehmann, and G. Patlewicz. Integrating data gap filling techniques: A case study predicting TEFs for neurotoxicity TEQs to facilitate the hazard assessment of polychlorinated biphenyls. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, USA, 101: 12-23, (2019).
Resources
4 resources available
-
Figures_code.zip
APPLICATION/X-ZIP-COMPRESSED -
NEQ-allAssays.csv
APPLICATION/VND.MS-EXCEL -
NEQ.csv
APPLICATION/VND.MS-EXCEL -
PCBs.csv
APPLICATION/VND.MS-EXCEL
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "020:00" ] |
| contactPoint |
{ "fn": "Ann Richard", "hasEmail": "mailto:richard.ann@epa.gov" } |
| description | The experimental data were taken from Simon et al., who compiled potency data for effects related to neurotoxicity from four experimental datasets, Stenberg et al. [18] and Wigestrand et al. The measures of potency were EC50 (µM) or IC50 values for all the effects except Stenberg data, which were expressed as a percentage of the control uptake for different concentrations measured. This dataset is associated with the following publication: Pradeep, P., L. Carlson, R. Judson, G. Lehmann, and G. Patlewicz. Integrating data gap filling techniques: A case study predicting TEFs for neurotoxicity TEQs to facilitate the hazard assessment of polychlorinated biphenyls. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, USA, 101: 12-23, (2019). |
| distribution |
[ { "title": "Figures_code.zip", "mediaType": "application/x-zip-compressed", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503181/Figures_code.zip" }, { "title": "NEQ-allAssays.csv", "mediaType": "application/vnd.ms-excel", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503181/NEQ-allAssays.csv" }, { "title": "NEQ.csv", "mediaType": "application/vnd.ms-excel", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503181/NEQ.csv" }, { "title": "PCBs.csv", "mediaType": "application/vnd.ms-excel", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503181/PCBs.csv" } ] |
| identifier | https://doi.org/10.23719/1503181 |
| keyword |
[ "DSSTox", "Neurotoxic equivalent factor (NEF)", "PCB congeners", "Toxic equivalency factors (TEFs)", "neurotoxicity", "qsar" ] |
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2018-08-22 |
| programCode |
[ "020:095" ] |
| publisher |
{ "name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": { "name": "U.S. Environmental Protection Agency", "subOrganizationOf": { "name": "U.S. Government" } } } |
| references |
[ "https://doi.org/10.1016/j.yrtph.2018.10.013" ] |
| rights |
null
|
| title | Integrating data gap filling techniques: A case study predicting TEFs for neurotoxicity TEQs to facilitate the hazard assessment of polychlorinated biphenyls |
