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In Vivo PK Library for IVIVE Evaluation

Metadata Updated: November 12, 2020

We report on new, in vivo TK experiments in rats for 26 chemicals more commonly associated with non-therapeutic and/or unintentional exposure. These chemicals, and an additional 19 chemicals from previously published in vivo rat studies, were systematically analyzed to estimate relevant TK parameters (e.g., volume of distribution, elimination rate). Our analysis created a library of TK parameters for 38 chemicals for which rat-specific in vitro HTTK data were also available.

This dataset is associated with the following publication: Wambaugh, J., M. Hughes, C. Ring, D. MacMillan, J. Ford, T. Fennell, S. Black, R. Snyder, N. Sipes, B. Wetmore, J. Westerhout, W. Setzer, R. Pearce, J. Simmons, and R. Thomas. Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 163(1): 152-169, (2018).

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Public: This dataset is intended for public access and use. License: See this page for license information.

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Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020

Metadata Source

Harvested from EPA ScienceHub

Additional Metadata

Resource Type Dataset
Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020
Publisher U.S. EPA Office of Research and Development (ORD)
Data Last Modified 2017-09-08
Public Access Level public
Bureau Code 020:00
Schema Version
Harvest Object Id 1238ceba-9279-48da-863f-e156f8282a1b
Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
Harvest Source Title EPA ScienceHub
Program Code 020:095
Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
Related Documents
Source Datajson Identifier True
Source Hash 3fe299b09a08c7529e6a5cda7540c39554887663
Source Schema Version 1.1

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