Impact of Scaling Factor Variability on Risk Relevant Outcomes in Children
This dataset contains physiologically-based (PBPK) model code and parameter settings supporting the manuscript titled "THE IMPACT OF SCALING FACTOR VARIABILITY ON RISK-RELEVANT PHARMACOKINETIC OUTCOMES IN CHILDREN: A CASE STUDY USING BROMODICHLOROMETHANE (BDCM)".
This dataset is associated with the following publication:
Kenyon, E., J. Lipscomb, R. Pegram, B. George, and R. Hines. THE IMPACT OF SCALING FACTOR VARIABILITY ON RISK-RELEVANT PHARMACOKINETIC OUTCOMES IN CHILDREN: A CASE STUDY USING BROMODICHLOROMETHANE (BDCM). TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 167(2): 347-359, (2019).
Resources
2 resources available
-
ModelFile_BDCM_peds.pdf
APPLICATION/PDF -
ModelParameters_PedsScalingVariability.pdf
APPLICATION/PDF
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "020:00" ] |
| contactPoint |
{ "fn": "Elaina Kenyon", "hasEmail": "mailto:kenyon.elaina@epa.gov" } |
| describedBy | https://pasteur.epa.gov/uploads/10.23719/1407661/documents/DataDictionary_PediatricScalingVariability.pdf |
| describedByType | application/pdf |
| description | This dataset contains physiologically-based (PBPK) model code and parameter settings supporting the manuscript titled "THE IMPACT OF SCALING FACTOR VARIABILITY ON RISK-RELEVANT PHARMACOKINETIC OUTCOMES IN CHILDREN: A CASE STUDY USING BROMODICHLOROMETHANE (BDCM)". This dataset is associated with the following publication: Kenyon, E., J. Lipscomb, R. Pegram, B. George, and R. Hines. THE IMPACT OF SCALING FACTOR VARIABILITY ON RISK-RELEVANT PHARMACOKINETIC OUTCOMES IN CHILDREN: A CASE STUDY USING BROMODICHLOROMETHANE (BDCM). TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 167(2): 347-359, (2019). |
| distribution |
[ { "title": "ModelFile_BDCM_peds.pdf", "mediaType": "application/pdf", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1407661/ModelFile_BDCM_peds.pdf" }, { "title": "ModelParameters_PedsScalingVariability.pdf", "mediaType": "application/pdf", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1407661/ModelParameters_PedsScalingVariability.pdf" } ] |
| identifier | https://doi.org/10.23719/1407661 |
| keyword |
[ "age-related susceptibility", "bromodichloromethane", "children", "global sensitivity analysis", "in vitro to in vivo extrapolation (IVIVE)", "pediatric", "scaling factors", "trihalomethanes", "variability" ] |
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2017-10-02 |
| programCode |
[ "020:096" ] |
| publisher |
{ "name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": { "name": "U.S. Environmental Protection Agency", "subOrganizationOf": { "name": "U.S. Government" } } } |
| references |
[ "https://doi.org/10.1093/toxsci/kfy236", "https://pasteur.epa.gov/uploads/10.23719/1407661/documents/PedsScalingFactorVariability_ModelSettings%26Inputs.pdf", "https://pasteur.epa.gov/uploads/10.23719/1407661/documents/SupplementalData_PedsScalingVariability.pdf" ] |
| rights |
null
|
| title | Impact of Scaling Factor Variability on Risk Relevant Outcomes in Children |
