Impact of Scaling Factor Variability on Risk Relevant Outcomes in Children
This dataset contains physiologically-based (PBPK) model code and parameter settings supporting the manuscript titled "THE IMPACT OF SCALING FACTOR VARIABILITY ON RISK-RELEVANT PHARMACOKINETIC OUTCOMES IN CHILDREN: A CASE STUDY USING BROMODICHLOROMETHANE (BDCM)".
This dataset is associated with the following publication:
Kenyon, E., J. Lipscomb, R. Pegram, B. George, and R. Hines. THE IMPACT OF SCALING FACTOR VARIABILITY ON RISK-RELEVANT PHARMACOKINETIC OUTCOMES IN CHILDREN: A CASE STUDY USING BROMODICHLOROMETHANE (BDCM). TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 167(2): 347-359, (2019).
Resources
2 resources available
-
ModelFile_BDCM_peds.pdf
APPLICATION/PDF -
ModelParameters_PedsScalingVariability.pdf
APPLICATION/PDF
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Elaina Kenyon",
"hasEmail": "mailto:kenyon.elaina@epa.gov"
}
|
| describedBy | https://pasteur.epa.gov/uploads/10.23719/1407661/documents/DataDictionary_PediatricScalingVariability.pdf |
| describedByType | application/pdf |
| description | This dataset contains physiologically-based (PBPK) model code and parameter settings supporting the manuscript titled "THE IMPACT OF SCALING FACTOR VARIABILITY ON RISK-RELEVANT PHARMACOKINETIC OUTCOMES IN CHILDREN: A CASE STUDY USING BROMODICHLOROMETHANE (BDCM)". This dataset is associated with the following publication: Kenyon, E., J. Lipscomb, R. Pegram, B. George, and R. Hines. THE IMPACT OF SCALING FACTOR VARIABILITY ON RISK-RELEVANT PHARMACOKINETIC OUTCOMES IN CHILDREN: A CASE STUDY USING BROMODICHLOROMETHANE (BDCM). TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 167(2): 347-359, (2019). |
| distribution |
[
{
"title": "ModelFile_BDCM_peds.pdf",
"mediaType": "application/pdf",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1407661/ModelFile_BDCM_peds.pdf"
},
{
"title": "ModelParameters_PedsScalingVariability.pdf",
"mediaType": "application/pdf",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1407661/ModelParameters_PedsScalingVariability.pdf"
}
]
|
| identifier | https://doi.org/10.23719/1407661 |
| keyword |
[
"age-related susceptibility",
"bromodichloromethane",
"children",
"global sensitivity analysis",
"in vitro to in vivo extrapolation (IVIVE)",
"pediatric",
"scaling factors",
"trihalomethanes",
"variability"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2017-10-02 |
| programCode |
[
"020:096"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1093/toxsci/kfy236",
"https://pasteur.epa.gov/uploads/10.23719/1407661/documents/PedsScalingFactorVariability_ModelSettings%26Inputs.pdf",
"https://pasteur.epa.gov/uploads/10.23719/1407661/documents/SupplementalData_PedsScalingVariability.pdf"
]
|
| rights |
null
|
| title | Impact of Scaling Factor Variability on Risk Relevant Outcomes in Children |
