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    • Hormone replacement therapy use dramatically increases breast oestrogen receptor expression in obese postmenopausal women

    Metadata Updated: September 6, 2025

    Background It is known that use of hormone replacement therapy (HRT) by postmenopausal women increases the risk of breast cancer.

          Method
      In this study, oestrogen receptor (ER)-α expression is examined using standard immunoperoxidase technique.


      Results
      Normal breast samples of 11 Australian postmenopausal women have been included in the ER-α study; the result showed a strong correlation (r2 = 0.80) between ER-α expression in normal breast epithelial cells and body mass index (BMI) in normal women who currently use HRT.


      Conclusion
      This finding confirms that the possibility of increased risk of breast cancer associated with increased ER-α expression in normal breast epithelial cells, in turn associated with high BMI and the use of HRT.

    Access & Use Information

    Public: This dataset is intended for public access and use. License: No license information was provided. If this work was prepared by an officer or employee of the United States government as part of that person's official duties it is considered a U.S. Government Work.

    Downloads & Resources

    Dates

    Metadata Created Date July 24, 2025
    Metadata Updated Date September 6, 2025

    Metadata Source

    Harvested from Healthdata.gov

    Other Data Resources

    Additional Metadata

    Resource Type Dataset
    Metadata Created Date July 24, 2025
    Metadata Updated Date September 6, 2025
    Publisher National Institutes of Health
    Maintainer
    NIH
    Identifier https://healthdata.gov/api/views/9i9f-mgix
    Data First Published 2025-07-14
    Data Last Modified 2025-09-06
    Category NIH
    Public Access Level public
    Bureau Code 009:25
    Metadata Context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
    Metadata Catalog ID https://healthdata.gov/data.json
    Schema Version https://project-open-data.cio.gov/v1.1/schema
    Catalog Describedby https://project-open-data.cio.gov/v1.1/schema/catalog.json
    Harvest Object Id e28a59a5-06ae-4416-9a26-464000eb36ca
    Harvest Source Id 651e43b2-321c-4e4c-b86a-835cfc342cb0
    Harvest Source Title Healthdata.gov
    Homepage URL https://healthdata.gov/d/9i9f-mgix
    Program Code 009:035
    Source Datajson Identifier True
    Source Hash 29bf607b9d09b011e4c340f726939b036cec9a3de5fe1f5592eb4b43f1a9b017
    Source Schema Version 1.1

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