Hormone replacement therapy use dramatically increases breast oestrogen receptor expression in obese postmenopausal women
Background
It is known that use of hormone replacement therapy (HRT) by postmenopausal women increases the risk of breast cancer.
Method
In this study, oestrogen receptor (ER)-α expression is examined using standard immunoperoxidase technique.
Results
Normal breast samples of 11 Australian postmenopausal women have been included in the ER-α study; the result showed a strong correlation (r2 = 0.80) between ER-α expression in normal breast epithelial cells and body mass index (BMI) in normal women who currently use HRT.
Conclusion
This finding confirms that the possibility of increased risk of breast cancer associated with increased ER-α expression in normal breast epithelial cells, in turn associated with high BMI and the use of HRT.
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "009:25" ] |
| contactPoint |
{ "fn": "NIH", "@type": "vcard:Contact", "hasEmail": "mailto:info@nih.gov" } |
| description | Background It is known that use of hormone replacement therapy (HRT) by postmenopausal women increases the risk of breast cancer. Method In this study, oestrogen receptor (ER)-α expression is examined using standard immunoperoxidase technique. Results Normal breast samples of 11 Australian postmenopausal women have been included in the ER-α study; the result showed a strong correlation (r2 = 0.80) between ER-α expression in normal breast epithelial cells and body mass index (BMI) in normal women who currently use HRT. Conclusion This finding confirms that the possibility of increased risk of breast cancer associated with increased ER-α expression in normal breast epithelial cells, in turn associated with high BMI and the use of HRT. |
| distribution |
[ { "@type": "dcat:Distribution", "title": "Official Government Data Source", "mediaType": "text/html", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC57804/" } ] |
| identifier | https://healthdata.gov/api/views/9i9f-mgix |
| issued | 2025-07-14 |
| keyword |
[ "breast-cancer-risk", "estrogen-receptor-alpha", "hormone-replacement-therapy", "nih", "postmenopausal-women" ] |
| landingPage | https://healthdata.gov/d/9i9f-mgix |
| modified | 2025-09-06 |
| programCode |
[ "009:035" ] |
| publisher |
{ "name": "National Institutes of Health", "@type": "org:Organization" } |
| theme |
[ "NIH" ] |
| title | Hormone replacement therapy use dramatically increases breast oestrogen receptor expression in obese postmenopausal women |
