This data release contains compiled historical groundwater-withdrawal data for the Coastal Lowlands aquifer system in Texas, Louisiana, Mississippi, Alabama, and Florida from 1925 to 2018. Most groundwater-withdrawals were distributed to groundwater wells and separated into water-use categories of industrial, production well, power generation, mining, domestic, irrigation, livestock or commercial. Groundwater-withdrawal data were obtained, where available, from existing database resources hosted by various State and Federal agencies. For Texas, data were obtained from the Texas Water Development Board (TWDB) from both existing Groundwater-Availability Models (GAM), and from historical groundwater-withdrawal data. For Louisiana data were obtained from the U.S. Geological Survey Lower Mississippi-Gulf Water Science Center, Baton Rouge, Louisiana office. For Mississippi data were obtained from the Mississippi Department of Environmental Quality, and from the U.S. Geological Survey Lower Mississippi-Gulf Water Science Center, Jackson, Mississippi. For Alabama data were obtained from the Alabama Department of Economic and Community Affairs, Office of Water Resources, and from the U.S. Geological Survey Lower Mississippi-Gulf Water Science Center, Montgomery, Alabama office. For Florida data were obtained from the U.S. Geological Survey Caribbean-Florida Water Science Center, Lutz and Orlando Florida offices.