This data release contains analytical results from 52 groundwater samples and six quality assurance and quality control samples collected from central New York and the Upper Hudson River Basin. Samples were collected between June and October, 2022 from 15 production wells and 16 domestic wells in central New York, and 11 production wells and 10 domestic wells in the Upper Hudson River Basin. Of the total wells sampled, 23 were completed in bedrock and 29 were completed in sand and gravel. Samples were collected prior to any treatment or filtration systems, from existing domestic and production wells equipped with permanently installed pumps. Samples were collected and processed using standard USGS methods (see References.csv) and were analyzed for constituents including physicochemical properties, dissolved gases, major ions, nutrients, trace elements, pesticides, volatile organic compounds (VOCs), radiological activity, and indicator bacteria. All analytes are listed with the associated method detection and reporting limits. Samples were analyzed at the USGS National Water Quality Laboratory (NWQL) in Denver, Colorado, and other certified laboratories following published methods (see References.csv).