This U.S. Geological Survey (USGS) data release presents a digital database of geospatially enabled vector layers and tabular data transcribed from the geologic map of the Lake Owen quadrangle, Albany County, Wyoming, which was originally published as U.S. Geological Survey Geologic Quadrangle Map GQ-1304 (Houston and Orback, 1976). The 7.5-minute Lake Owen quadrangle is located in southeastern Wyoming approximately 25 miles (40 kilometers) southwest of Laramie in the west-central interior of southern Albany County, and covers most of the southern extent of Sheep Mountain, the southeastern extent of Centennial Valley, and a portion of the eastern Medicine Bow Mountains. This relational geodatabase, with georeferenced data layers digitized at the publication scale of 1:24,000, organizes and describes the geologic and structural data covering the quadrangle's approximately 35,954 acres and enables the data for use in spatial analyses and computer cartography. The data types presented in this release include geospatial features (points, lines, and polygons) with matching attribute tables, nonspatial descriptive and reference tables, and ancillary resource files for correct symbolization, in formats that conform to the Geologic Map Schema (GeMS) developed and released by the U.S. Geological Survey's National Cooperative Geologic Mapping Program (GeMS, 2020). When reconstructed from the geodatabase's vector layers and tabular data that has been symbolized according to specifications encoded in the accompanying style file, and using the supplied Federal Geographic Data Committee (FGDC) GeoAge font for labeling formations and GeoSym fonts for structural line decorations and orientation measurement symbols, this data release presents the Geologic Map as shown on the published GQ-1304 map sheet. These GIS data augment but do not supersede the information presented on GQ-1304. References: Houston, R.S., and Orback, C.J., 1976, Geologic Map of the Lake Owen Quadrangle, Albany County, Wyoming: U.S. Geological Survey Geologic Quadrangle Map GQ-1304, scale 1:24,000, https://doi.org/10.3133/gq1304. U.S. Geological Survey National Cooperative Geologic Mapping Program, 2020, GeMS (Geologic Map Schema)- A standard format for the digital publication of geologic maps: U.S. Geological Survey Techniques and Methods, book 11, chap. B10, 74 p., https://doi.org//10.3133/tm11B10.