This U.S. Geological Survey data release consists multiple datasets used to simulate the extents of flood inundation along the Muddy River, near Moapa, Nevada. Flood-inundation extents equal the maximum area of flood inundation and were estimated using a coupled one-dimensional (1D) and two-dimensional (2D) hydraulic model. The modeled extents represent six annual exceedance probabilities simulated for the current (2019) levee location adjacent to the Muddy River and a new levee location associated with a proposed restoration of a selected reach along the Muddy River. The data release includes: 1) a polygon dataset of the flood-inundation extents (MuddyRiver_Flood_Inundation_p.shp); 2) a zip file containing all relevant files to document and run the PeakFQ flood-frequency analysis used as input into the hydraulic model (0941600_Flood_Frequency_Archive.zip); 3) a zip file containing all relevant files to document and run the coupled 1D and 2D Hydrological Engineering Center-River Analysis System (HEC-RAS) hydraulic model used to generate a polygon dataset of flood-inundation extents (SWmodel_Archive.zip); 4) a polygon dataset of the current and proposed levee locations (MuddyRiver_Levee_p.shp); 5) a point dataset of survey points (RTK-TS_survey_x.shp) collected from April 1 to August 9, 2019, using real-time kinematic global navigation satellite system (GNSS) and total station (TS); and 6) a point dataset of seven static reference locations (Static_GNSS_x.shp) collected from March 29 to August 9, 2019, using a single-baseline online positioning user service – static (OPUS-S) GNSS survey.