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Generalised Read-Across (GenRA) refinements
These new analysis builds on the baseline GenRA approach and presents a proof of concept of how other contexts of similarity namely physchem can be implemented into a search strategy for identification of analogues and how this impacts performance of read-across. Chemicals Involved: Same ToxRef dataset as used in the original GenRA manuscript.
This dataset is associated with the following publication:
Helman, G., I. Shah, and G. Patlewicz. Extending the Generalised Read-Across approach (GenRA): A systematic analysis of the impact of physicochemical property information on read-across performance. Computational Toxicology. Elsevier B.V., Amsterdam, NETHERLANDS, 8: 34-50, (2018).
Resources
1 resource available
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https://gaftp.epa.gov/COMPTOX/NCCT_Publication_Data/PatlewiczGrace/Extending_the_Generalised_Read-Across_approach_(GenRA)_A_systematic_analysis_of_the_impact_of_physicochemical_property_information_on_read-across_performance/
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "020:00" ] |
| contactPoint |
{ "fn": "Ann Richard", "hasEmail": "mailto:richard.ann@epa.gov" } |
| description | These new analysis builds on the baseline GenRA approach and presents a proof of concept of how other contexts of similarity namely physchem can be implemented into a search strategy for identification of analogues and how this impacts performance of read-across. Chemicals Involved: Same ToxRef dataset as used in the original GenRA manuscript. This dataset is associated with the following publication: Helman, G., I. Shah, and G. Patlewicz. Extending the Generalised Read-Across approach (GenRA): A systematic analysis of the impact of physicochemical property information on read-across performance. Computational Toxicology. Elsevier B.V., Amsterdam, NETHERLANDS, 8: 34-50, (2018). |
| distribution |
[ { "title": "https://gaftp.epa.gov/COMPTOX/NCCT_Publication_Data/PatlewiczGrace/Extending_the_Generalised_Read-Across_approach_(GenRA)_A_systematic_analysis_of_the_impact_of_physicochemical_property_information_on_read-across_performance/", "accessURL": "https://gaftp.epa.gov/COMPTOX/NCCT_Publication_Data/PatlewiczGrace/Extending_the_Generalised_Read-Across_approach_(GenRA)_A_systematic_analysis_of_the_impact_of_physicochemical_property_information_on_read-across_performance/" } ] |
| identifier | https://doi.org/10.23719/1503179 |
| keyword |
[ "DSSTox", "GenRA", "Read-across", "ToxCast", "generalised read-across", "physiochemical parameters" ] |
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2019-04-01 |
| programCode |
[ "020:095" ] |
| publisher |
{ "name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": { "name": "U.S. Environmental Protection Agency", "subOrganizationOf": { "name": "U.S. Government" } } } |
| references |
[ "https://doi.org/10.1016/j.comtox.2018.07.001" ] |
| rights |
null
|
| title | Generalised Read-Across (GenRA) refinements |
