Modern space propulsion and exploration system designs are becoming increasingly sophisticated and complex. Determining the health state of these systems using traditional methods is becoming more difficult as the number of sensors and component interactions grows. Data-driven monitoring techniques have been developed to address these issues by analyzing system operations data to automatically characterize normal system behavior. The Inductive Monitoring System is a data-driven system health monitoring software tool that has been successfully applied to several aerospace applications. Inductive Monitoring System uses a data mining technique called clustering to analyze archived system data and characterize normal interactions between parameters. This characterization, or model, of nominal operation is stored in a knowledge base that can be used for real-time system monitoring or for analysis of archived events. Ongoing and developing Inductive Monitoring System space operations applications include International Space Station flight control, spacecraft vehicle system health management, launch vehicle ground operations, and fleet supportability. As a common thread of discussion this paper will employ the evolution of the Inductive Monitoring System data-driven technique as related to several Integrated Systems Health Management elements. Thematically, the projects listed will be used as case studies. The maturation of Inductive Monitoring System via projects where it has been deployed or is currently being integrated to aid in fault detection will be described. The paper will also explain how Inductive Monitoring System can be used to complement a suite of other Integrated System Health Management tools, providing initial fault detection support for diagnosis and recovery.