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Fox River kindling Bandara et al Summary Data
This study looked at functional endpoints in adult offspring of rats exposed in utero and postnatally to an environmentally relevant mixture of PCBs, Fox River blend. A model of neural plasticity and epilepsy, electrical kindling, was examined. Animals exposed to PCBs had slower kindling rates suggesting impaired plasticity mechanisms, consistent with previous work with PCBs where deficits were seen in another plasticity model, long-term potentiation.
This dataset is associated with the following publication:
Bandara, S., R. Sadowski, S. Schantz, and M. Gilbert. Developmental Exposure to an Environmental PCB Mixture Delays the Propagation of Kindling in the Amygdala. NEUROTOXICOLOGY. Elsevier B.V., Amsterdam, NETHERLANDS, n/a, (2016).
Resources
1 resource available
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Fox River Kindling Bandara et al Summary Data.xlsx
APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "020:00" ] |
| contactPoint |
{ "fn": "Mary Gilbert", "hasEmail": "mailto:gilbert.mary@epa.gov" } |
| description | This study looked at functional endpoints in adult offspring of rats exposed in utero and postnatally to an environmentally relevant mixture of PCBs, Fox River blend. A model of neural plasticity and epilepsy, electrical kindling, was examined. Animals exposed to PCBs had slower kindling rates suggesting impaired plasticity mechanisms, consistent with previous work with PCBs where deficits were seen in another plasticity model, long-term potentiation. This dataset is associated with the following publication: Bandara, S., R. Sadowski, S. Schantz, and M. Gilbert. Developmental Exposure to an Environmental PCB Mixture Delays the Propagation of Kindling in the Amygdala. NEUROTOXICOLOGY. Elsevier B.V., Amsterdam, NETHERLANDS, n/a, (2016). |
| distribution |
[ { "title": "Fox River Kindling Bandara et al Summary Data.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503125/Fox%20River%20Kindling%20Bandara%20et%20al%20Summary%20Data.xlsx" } ] |
| identifier | https://doi.org/10.23719/1503125 |
| keyword |
[ "children's health", "developmental hypothryoidism", "neruotoxicity", "polyclorinated biphenyls", "thyroid hormone" ] |
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2018-10-25 |
| programCode |
[ "020:095" ] |
| publisher |
{ "name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": { "name": "U.S. Environmental Protection Agency", "subOrganizationOf": { "name": "U.S. Government" } } } |
| references |
[ "https://doi.org/10.1016/j.neuro.2016.10.016" ] |
| rights |
null
|
| title | Fox River kindling Bandara et al Summary Data |
