Digital flood-inundation maps for a 9.3-mile reach of the Iowa River along the Meskwaki Settlement, Iowa, were created by the U.S. Geological Survey (USGS) in cooperation with the Sac and Fox Tribe of the Mississippi River in Iowa. The flood-inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science web site at https://water.usgs.gov/osw/flood_inundation/ depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage 05451770 on the Iowa River at County Highway E49 near Tama, Iowa. Near-real-time stages at this streamgage may be obtained on the internet from the USGS National Water Information System at https://waterdata.usgs.gov/ or the National Weather Service (NWS) Advanced Hydrologic Prediction Service at https://water.weather.gov/ahps/, which also forecasts flood hydrographs at this site. Flood profiles were computed for the stream reach by means of a calibrated one-dimensional and two-dimensional step-backwater hydraulic model. The model was calibrated by using the current stage-discharge relation at the USGS streamgage 05451770 on the Iowa River at County Highway E49 near Tama, Iowa, and stage and discharge data from historic flooding events that were recorded at the streamgage. The hydraulic model was then used to compute eight water-surface profiles for flood stages at 1-foot intervals referenced to the streamgage datum and ranging from the NWS “action stage” of 11 feet (ft) to 18 ft, the stage exceeding the estimated 0.2-percent annual exceedance probability (500-year recurrence interval) flood, as determined at the USGS streamgage 05451770 on the Iowa River at County Highway E49 near Tama, Iowa. The simulated water-surface profiles were then combined with a geographic information system digital elevation model (DEM) to delineate the area flooded at each flood stage (water level). The availability of these maps, along with internet information regarding current stage from the USGS streamgage and forecasted high-flow stages from the NWS, will provide emergency management personnel and residents with information that is critical for flood-response activities such as evacuations and road closures, as well as for postflood recovery efforts.