Digital flood-inundation maps for a 4.46-mile reach of the Blue River near Kansas City, Missouri, were created by the U.S. Geological Survey (USGS) in cooperation with the City of Kansas City, Missouri. The flood-inundation maps, accessed through the USGS Flood Inundation Mapping Program website at http://water.usgs.gov/osw/flood_inundation/ , depict estimates of the spatial extent and depth of flooding corresponding to select-water levels (stages) at the USGS streamgage 06893195 Blue River at Red Bridge Road, Kansas City, Missouri reference streamgage. Near-real-time stage data from the streamgage may be obtained from the USGS National Water Information System database at https://doi.org/10.5066/F7P55KJN. Flood profiles were computed for the reach by means of a one-dimensional hydraulic model. The model was calibrated by using the current stage-streamflow relations at USGS streamgages upstream and downstream from the study reach. The hydraulic model was used to compute water-surface profiles for flood stages at 1-foot intervals referenced to the streamgage datum ranging from the estimated bankfull streamflow, through the stage corresponding to, or exceeding, the estimated 0.2-percent annual exceedance probability flood (500-year recurrence interval flood). The simulated water-surface profiles were then combined with a geographic information system digital elevation model with a maximum 10-centimeter vertical root mean square error and 4.0-ft horizontal resolution to delineate the area flooded at each 1-foot increment of stage. The availability of these maps, along with information regarding current stage from the USGS streamgage and forecasted high-flow stages from the National Weather Service, will provide emergency management personnel and residents with information that is critical for flood mitigation, preparedness and planning, flood-response activities such as evacuations and road closures, as well as for post flood recovery efforts. The depth grid data are provided in Tagged Image Format Files (.tiff) and compressed into a .zip archive that is named BlueRKCMO_depthgrids.zip.